CAJ | 학술논문

近年来,桥本甲状腺炎和甲状腺癌(尤其是乳头状甲状腺癌)患病率均呈上升趋势,桥本甲状腺炎合并甲状腺癌也逐年增加.桥本甲状腺炎与甲状腺癌相关性的机制尚未明了,目前有共同病因学说、癌前病变学说、淋巴细胞浸润学说3种观点,其中共同病因包括辐射、高碘、免疫及促甲状腺激素作用等,在共同病因作用下,桥本甲状腺炎、甲状腺癌患病率均升高.一些分子在桥本甲状腺炎和甲状腺癌高表达,与甲状腺其他疾病存在表达差异,可预测桥本甲状腺炎与甲状腺癌的相关性.甲状腺癌灶周围组织淋巴细胞的浸润也可能与桥本甲状腺炎相关.
근년래,교본갑상선염화갑상선암(우기시유두상갑상선암)환병솔균정상승추세,교본갑상선염합병갑상선암야축년증가.교본갑상선염여갑상선암상관성적궤제상미명료,목전유공동병인학설、암전병변학설、림파세포침윤학설3충관점,기중공동병인포괄복사、고전、면역급촉갑상선격소작용등,재공동병인작용하,교본갑상선염、갑상선암환병솔균승고.일사분자재교본갑상선염화갑상선암고표체,여갑상선기타질병존재표체차이,가예측교본갑상선염여갑상선암적상관성.갑상선암조주위조직림파세포적침윤야가능여교본갑상선염상관.
Recently,the prevalence of Hashimoto's thyroiditis or thyroid carcinoma (especially the thyroid papillary carcinoma) is increasing,and more and more people are suffering from Hashimoto's thyroiditis complicated with thyroid carcinoma.The mechanism of the association between Hashimoto's thyroiditis and thyroid carcinoma is unclear,but there are many hypothesis including the common etiology,precancerous lesions,lymphocyte infiltration.The common causes include radiation,high iodine intake,immune and high thyroid stimulating hormone function.Under these common causes,the prevalence of Hashimoto's thyroiditis and thyroid cancer increases.There are common molecular biological factors between Hashimoto's thyroiditis and thyroid cancer.Expression of some moleculars in Hashimoto's thyroiditis and thyroid cancer are higher than other thyroid diseases.These molecules can predict the correlation of Hashimoto's thyroiditis and thyroid cancer.Infiltration of lymphocytes in the surrounding area of thyroid cancer tissue may imply the association of Hashimoto's thyroiditis with thyroid cancer.