CAJ | 학술논문

目的探讨神经节苷脂联合纳洛酮治疗新生儿缺氧缺血性脑病(HIE)的临床疗效.方法将98例HIE患儿随机分为两组,对照组49例患儿在常规治疗的基础上加用纳洛酮治疗,观察组49例患儿则在对照组的基础上加用神经节苷脂治疗,比较两组临床疗效.结果观察组总有效率为93.88％,明显高于对照组的71.43％(P＜0.05);治疗7d和14d后,观察组新生儿神经行为评分(NBNA)明显高于对照组(P＜0.05).结论神经节苷脂联合纳洛酮治疗HIE患儿疗效确切,可明显改善患儿脑功能,无明显不良反应,值得临床大力推广应用.
목적 탐토신경절감지연합납락동치료신생인결양결혈성뇌병(HIE)적림상료효.방법 장98례HIE환인수궤분위량조,대조조49례환인재상규치료적기출상가용납락동치료,관찰조49례환인칙재대조조적기출상가용신경절감지치료,비교량조림상료효.결과 관찰조총유효솔위93.88％,명현고우대조조적71.43％(P＜0.05);치료7d화14d후,관찰조신생인신경행위평분(NBNA)명현고우대조조(P＜0.05).결론 신경절감지연합납락동치료HIE환인료효학절,가명현개선환인뇌공능,무명현불량반응,치득림상대력추엄응용.
Objective To investigate the clinical efficacy of combination therapy with ganglioside and naloxone for neonatal hypoxic-ischemic encephalopathy (HIE).Methods 98 neonates with HIE were randomly assigned to receive naloxone in addition to conventional therapy (49 neonates,control group),or naloxone combined with ganglioside in addition to conventional treatment (49 neonates,study group).The clinical efficacy was compared between the two groups.Results The total effectiveness rate was significantly higher in the study group than in the control group (93.88％ vs.71.43％,P ＜ 0.05).Scores on the NBNA were significantly higher in the study group than in the control group on days 7 and 14(P ＜ 0.05).Conclusions Combination therapy with ganglioside and aloxone can significantly improve brain function.It is efficacious and has no significant adverse reactions and thus is worth popularizing clinically.