中华器官移植杂志
中華器官移植雜誌
중화기관이식잡지
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
2014年
7期
392-395
,共4页
项和立%薛武军%田普训%丁小明%潘晓鸣%燕航%侯军%冯新顺%刘林娟
項和立%薛武軍%田普訓%丁小明%潘曉鳴%燕航%侯軍%馮新順%劉林娟
항화립%설무군%전보훈%정소명%반효명%연항%후군%풍신순%류림연
公民逝世后器官捐献%供者%评估%维护%肾移植
公民逝世後器官捐獻%供者%評估%維護%腎移植
공민서세후기관연헌%공자%평고%유호%신이식
Donation after citizens death%Donor%Evaluation%Maintenance%Kidney transplantation
目的 总结公民逝世后器官捐献(DCD)供者评估和维护的经验.方法 回顾性分析2011年12月至2014年4月间共实施的112例DCD器官捐献和211例DCD供肾移植的临床资料.对供者的评估和维护及移植效果进行分析.结果 实施112例DCD中,中国三类98例,中国二类14例.获取肾脏222个,实施肾移植211例.急性排斥反应发生率7.1％(115/211),移植肾功能恢复延迟(DGF)发生率11.4％(24/211).接受原发病为脑血管意外供者供肾移植的受者术后1和6个月的估算肾小球滤过率(eGFR)显著低于接受其他原发病供者供肾移植的受者(P＜0.01).器官获取前无低血压和未行心肺复苏供者的eGFR显著高于有低血压和进行过心肺复苏的供者(P＜0.01)),且前者相应受者的移植后eGFR更高(P＜0.05).应用LifePort(R)机械灌注后DGF发生率显著降低(P＜0.05).结论 早期正确的DCD供者的评估和维护能够获得更高质量的移植器官和更好的移植效果.
目的 總結公民逝世後器官捐獻(DCD)供者評估和維護的經驗.方法 迴顧性分析2011年12月至2014年4月間共實施的112例DCD器官捐獻和211例DCD供腎移植的臨床資料.對供者的評估和維護及移植效果進行分析.結果 實施112例DCD中,中國三類98例,中國二類14例.穫取腎髒222箇,實施腎移植211例.急性排斥反應髮生率7.1％(115/211),移植腎功能恢複延遲(DGF)髮生率11.4％(24/211).接受原髮病為腦血管意外供者供腎移植的受者術後1和6箇月的估算腎小毬濾過率(eGFR)顯著低于接受其他原髮病供者供腎移植的受者(P＜0.01).器官穫取前無低血壓和未行心肺複囌供者的eGFR顯著高于有低血壓和進行過心肺複囌的供者(P＜0.01)),且前者相應受者的移植後eGFR更高(P＜0.05).應用LifePort(R)機械灌註後DGF髮生率顯著降低(P＜0.05).結論 早期正確的DCD供者的評估和維護能夠穫得更高質量的移植器官和更好的移植效果.
목적 총결공민서세후기관연헌(DCD)공자평고화유호적경험.방법 회고성분석2011년12월지2014년4월간공실시적112례DCD기관연헌화211례DCD공신이식적림상자료.대공자적평고화유호급이식효과진행분석.결과 실시112례DCD중,중국삼류98례,중국이류14례.획취신장222개,실시신이식211례.급성배척반응발생솔7.1％(115/211),이식신공능회복연지(DGF)발생솔11.4％(24/211).접수원발병위뇌혈관의외공자공신이식적수자술후1화6개월적고산신소구려과솔(eGFR)현저저우접수기타원발병공자공신이식적수자(P＜0.01).기관획취전무저혈압화미행심폐복소공자적eGFR현저고우유저혈압화진행과심폐복소적공자(P＜0.01)),차전자상응수자적이식후eGFR경고(P＜0.05).응용LifePort(R)궤계관주후DGF발생솔현저강저(P＜0.05).결론 조기정학적DCD공자적평고화유호능구획득경고질량적이식기관화경호적이식효과.
Objective To summarize the experience of donor evaluation and maintenance of donation after citizens death (DCD).Method A retrospective analysis on the clinical data of 112 cases of DCD and 211 cases of DCD donor renal transplantation was done from December 2011 to April 2014.Donor evaluation and maintenance was performed as early as possible Result 112 DCD cases were performed,including 14 cases of C-Ⅱ and 98 cases of C-Ⅲ.222 donated kidneys were harvested,211 kidneys for transplantations.Among 211 cases of renal transplant recipients,the incidence of acute rejection (AR) was 7.1 ％ (15/211),and that of postoperative renal delayed graft function (DGF) was 11.4％ (24/211).The recipient estimated glomerular filtration rate (eGFR) at 1st and 6th month after cadaver renal transplantation from donors by cerebrovascular accident was lower than that by all other causes (P ＜ 0.01).The donor eGFR was lower in donors with hypotension and cardio-pulmonary resuscitation (P＜0.01),and the recipient eGFR was lower in the recipients from donors with hypotension and cardio-pulmonary resuscitation (P ＜ 0.05).DGF incidence of using LifePort(R) was lower than that of not using LifePort(R) significantly (P＜0.05).Conclusion Early and correct evaluation and maintenance of the potential organ donor allows better quality of donated organs and transplant outcomes.
