浙江外国语学院学报
浙江外國語學院學報
절강외국어학원학보
JOURNAL OF ZHEJIANG EDUCATION INSTITUTE
2013年
4期
1-6
,共6页
齐多夫定( AZT)%热分析%热重-傅立叶红外联用%量子化学%热分解机理
齊多伕定( AZT)%熱分析%熱重-傅立葉紅外聯用%量子化學%熱分解機理
제다부정( AZT)%열분석%열중-부립협홍외련용%양자화학%열분해궤리
zidovudine ( AZT )%thermal analysis%TGA-FTIR%quantum chemistry%mechanism of the thermal decomposition
采用同步热分析（ TGA-DTG-DSC ）和热重-傅立叶红外（ TGA-FTIR ）联用技术研究齐多夫定（ AZT）在氮气气氛和空气气氛中的热分解过程，测定AZT及其在热分解过程中不同阶段气体产物和固体残留物的红外光谱，运用量子化学GAMESS软件计算AZT分子的键级，探讨AZT的热分解机理。研究结果表明，AZT的热分解过程是一个三阶段过程，起始热分解步骤是联接胸腺嘧啶环与四氢呋喃环的C-N 键的断裂，热分解中间残留物是胸腺嘧啶。
採用同步熱分析（ TGA-DTG-DSC ）和熱重-傅立葉紅外（ TGA-FTIR ）聯用技術研究齊多伕定（ AZT）在氮氣氣氛和空氣氣氛中的熱分解過程，測定AZT及其在熱分解過程中不同階段氣體產物和固體殘留物的紅外光譜，運用量子化學GAMESS軟件計算AZT分子的鍵級，探討AZT的熱分解機理。研究結果錶明，AZT的熱分解過程是一箇三階段過程，起始熱分解步驟是聯接胸腺嘧啶環與四氫呋喃環的C-N 鍵的斷裂，熱分解中間殘留物是胸腺嘧啶。
채용동보열분석（ TGA-DTG-DSC ）화열중-부립협홍외（ TGA-FTIR ）련용기술연구제다부정（ AZT）재담기기분화공기기분중적열분해과정，측정AZT급기재열분해과정중불동계단기체산물화고체잔류물적홍외광보，운용양자화학GAMESS연건계산AZT분자적건급，탐토AZT적열분해궤리。연구결과표명，AZT적열분해과정시일개삼계단과정，기시열분해보취시련접흉선밀정배여사경부남배적C-N 건적단렬，열분해중간잔류물시흉선밀정。
The thermal decomposition process of zidovudine ( AZT ) was studied by means of thermo-gravimetry ( TG) ,differential scanning calorimetry( DSC) ,and thermogravimetric analysis coupled with Fou-rier transform infrared spectroscopy(TGA-FTIR).The infrared spectra of AZT,its gaseous products and re-mainders from thermal decomposition at various temperatures were determined. The molecular bond orders were calculated by GAMESS method of quantum chemistry,and the mechanism of the thermal decomposition of AZT was discussed.The results indicated that the thermal decomposition of AZT was a three-stage process. Disconnection of the C-N bond between thymine ring and tetrahydrofuran ring occurred in the initial step of the decomposition,and the intermediate was confirmed as thymine.
