CAJ | 학술논문

目的：探讨外周血中嗜酸性粒细胞(peripheral blood eosinophil ce11, PBEC)计数、人白介素-13（interleukin-13，IL-13）和人白介素-4（interleukin-4，IL-4）水平的表达在过敏性皮炎发生发展中的作用。方法：收集28例过敏性皮炎患者和40例健康查体者外周血标本，常规计数PBEC，并通过半定量酶联免疫吸附试验（ELISA）检测上述标本中的IL-13和IL-4的水平，采用t检验比较其间的差异。结果：过敏性皮炎患者外周血PBEC计数、IL-13和IL-4的水平显著高于健康对照组(P<0.01)，且过敏性皮炎组IL-13和IL-4水平呈显著正相关性(P<0.05)。结论：PBEC、IL-13和IL-4参与过敏性皮炎患者体内的变态反应，IL-13可能通过IL-4来发挥作用。
목적：탐토외주혈중기산성립세포(peripheral blood eosinophil ce11, PBEC)계수、인백개소-13（interleukin-13，IL-13）화인백개소-4（interleukin-4，IL-4）수평적표체재과민성피염발생발전중적작용。방법：수집28례과민성피염환자화40례건강사체자외주혈표본，상규계수PBEC，병통과반정량매련면역흡부시험（ELISA）검측상술표본중적IL-13화IL-4적수평，채용t검험비교기간적차이。결과：과민성피염환자외주혈PBEC계수、IL-13화IL-4적수평현저고우건강대조조(P<0.01)，차과민성피염조IL-13화IL-4수평정현저정상관성(P<0.05)。결론：PBEC、IL-13화IL-4삼여과민성피염환자체내적변태반응，IL-13가능통과IL-4래발휘작용。
Objective:To investigate the correlation of PBEC, IL-4, IL-13 and atopic dermatitis. Methods:The counting of peripheral blood eosinophil cells (PBEC) was performed by the routine method,and the level of serum IL-4 and IL-13 in 28 atopic dermatitis patients and 40 health adults was measured by ELISA.Results:The amount of PBEC ,the level of serum IL-4 and IL-13 in atopic dermatitis group was significantly higher than that in the health control (P<0.01) , and there was a positive correlation between IL-4 and IL-13 in atopic dermatitis group(P<0.05). Conclusions:There is an important role of PBEC, IL-4 and IL-13 in atopic dermatitis, and IL-13 IL-13 May play a role by IL-4.