CAJ | 학술논문

目的：探讨首发精神分裂症患者服用利培酮对血清β2-微球蛋白及超敏C反应蛋白的影响。方法：对60例单服用利培酮治疗的首发精神分裂症患者进行治疗前、治疗后4周、治疗后8周的血清β2-微球蛋白及超敏C反应蛋白检测分析，并与60名健康者(对照组)进行比较。结果：精神分裂症患者服用利培酮药物在治疗前与治疗后8周的血清β2-微球蛋白分析对比有统计学差异（P<0.05）；血清超敏C反应蛋白水平在治疗前及治疗后4周的分析对比，有统计学差异（P<0.05）；血清超敏C反应蛋白水平在治疗前与治疗后8周分析对比，有统计学显著差异（P<0.01）。结论：长时间服用抗精神病药利培酮可导致精神分裂症患者血清β2-微球蛋白及超敏C反应蛋白代谢异常。
목적：탐토수발정신분렬증환자복용리배동대혈청β2-미구단백급초민C반응단백적영향。방법：대60례단복용리배동치료적수발정신분렬증환자진행치료전、치료후4주、치료후8주적혈청β2-미구단백급초민C반응단백검측분석，병여60명건강자(대조조)진행비교。결과：정신분렬증환자복용리배동약물재치료전여치료후8주적혈청β2-미구단백분석대비유통계학차이（P<0.05）；혈청초민C반응단백수평재치료전급치료후4주적분석대비，유통계학차이（P<0.05）；혈청초민C반응단백수평재치료전여치료후8주분석대비，유통계학현저차이（P<0.01）。결론：장시간복용항정신병약리배동가도치정신분렬증환자혈청β2-미구단백급초민C반응단백대사이상。
Objective:To investigate how taking risperidone by first-episode schizophrenia patients affects serum beta 2-microglobulin and high-sensitivity C-reactive protein. Methods:test and analyze serum beta 2-microglobulin and high-sensitivity C-reactive protein of 60 cases of risperidone treatment on first-episode schizophrenic patients before treatment, 4 weeks after treatment and 8 weeks after treatment and 60 healthy subjects (control group) were compared.Results:analyze and compare serum beta 2-microglobulin from the patients with schizophrenia who took risperidone before before treatment and 8 weeks after treatment and find significantly statistical difference (P <0.05); analyze and compare serum high-sensitivity C-reactive protein level and find significantly statistical difference (P <0.05); analyze and compare serum high sensitivity C-reactive protein levels and find significantly statistical differences (P <0.01). Conclusions:taking the antipsychotics risperidone for a long time can bring schizophrenia patients metabolic abnormalities of serum beta 2-microglobulin and high-sensitivity C-reactive protein.