医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2013年
5期
7-9,26
,共4页
卓雪芽%邓秋萍%庄健海%陈家钖
卓雪芽%鄧鞦萍%莊健海%陳傢钖
탁설아%산추평%장건해%진가양
系统性红斑狼疮%联合检测%活动性
繫統性紅斑狼瘡%聯閤檢測%活動性
계통성홍반랑창%연합검측%활동성
Systemic Lupus Erythematosus%Combined detection%Activity
目的：探讨多项检验指标联合检测在评价系统性红斑狼疮（SLE）活动性的应用。方法：对48例狼疮性肾炎患者、62例非狼疮性肾炎SLE患者用魏氏法测定血沉（ESR）,对两类患者平行用AU5400全自动生化分析仪检测C反应蛋白（CRP）、免疫球蛋白IgG、IgM、IgA、补体C3及C4,用Mejer-600尿化学分析仪+ UF-1000i尿沉沉渣分析仪组合检测尿常规，用XT-1800i全自动血细胞分析仪检测血常规,记录相关结果并进行统计分析。结果：狼疮性肾炎患者的ESR、CRP、IgG、IgM、IgA、C3及C4异常结果比率分别为89.58%、58.33%、54.16%、6.25%、37.50%、50.00%及77.08%，而非狼疮性肾炎SLE患者则分别为72.58%、29.03%、38.71%、4.84%、33.87%、12.90%及17.74%,两组ESR、CRP、C3及C4的差异有统计学意义(P<0.05)；狼疮性肾炎患者血常规指标RBC、WBC、PLT及HGB异常结果比率为31.25%、33.33%、29.16%及47.92%，非狼疮性肾炎SLE患者则分别为14.51%、11.29%、9.68%及18.87%,两组WBC和PLT的差异有统计学意义(P<0.05)；狼疮性肾炎患者尿常规指标BLO、PRO、LEU、RBC及WBC异常结果比率为60.42%、41.67%、37.50%、43.75%及33.33%,非狼疮性肾炎SLE患者则分别为27.42%、3.23%、16.13%、24.19%及25.81%,两组BLO、PRO、LEU、RBC及WBC的差异有统计学意义(P<0.05)。结论：多项检验指标联合检测可为全身多系统损害提示信息，对系统性红斑狼疮活动性判定有重要意义。
目的：探討多項檢驗指標聯閤檢測在評價繫統性紅斑狼瘡（SLE）活動性的應用。方法：對48例狼瘡性腎炎患者、62例非狼瘡性腎炎SLE患者用魏氏法測定血沉（ESR）,對兩類患者平行用AU5400全自動生化分析儀檢測C反應蛋白（CRP）、免疫毬蛋白IgG、IgM、IgA、補體C3及C4,用Mejer-600尿化學分析儀+ UF-1000i尿沉沉渣分析儀組閤檢測尿常規，用XT-1800i全自動血細胞分析儀檢測血常規,記錄相關結果併進行統計分析。結果：狼瘡性腎炎患者的ESR、CRP、IgG、IgM、IgA、C3及C4異常結果比率分彆為89.58%、58.33%、54.16%、6.25%、37.50%、50.00%及77.08%，而非狼瘡性腎炎SLE患者則分彆為72.58%、29.03%、38.71%、4.84%、33.87%、12.90%及17.74%,兩組ESR、CRP、C3及C4的差異有統計學意義(P<0.05)；狼瘡性腎炎患者血常規指標RBC、WBC、PLT及HGB異常結果比率為31.25%、33.33%、29.16%及47.92%，非狼瘡性腎炎SLE患者則分彆為14.51%、11.29%、9.68%及18.87%,兩組WBC和PLT的差異有統計學意義(P<0.05)；狼瘡性腎炎患者尿常規指標BLO、PRO、LEU、RBC及WBC異常結果比率為60.42%、41.67%、37.50%、43.75%及33.33%,非狼瘡性腎炎SLE患者則分彆為27.42%、3.23%、16.13%、24.19%及25.81%,兩組BLO、PRO、LEU、RBC及WBC的差異有統計學意義(P<0.05)。結論：多項檢驗指標聯閤檢測可為全身多繫統損害提示信息，對繫統性紅斑狼瘡活動性判定有重要意義。
목적：탐토다항검험지표연합검측재평개계통성홍반랑창（SLE）활동성적응용。방법：대48례랑창성신염환자、62례비랑창성신염SLE환자용위씨법측정혈침（ESR）,대량류환자평행용AU5400전자동생화분석의검측C반응단백（CRP）、면역구단백IgG、IgM、IgA、보체C3급C4,용Mejer-600뇨화학분석의+ UF-1000i뇨침침사분석의조합검측뇨상규，용XT-1800i전자동혈세포분석의검측혈상규,기록상관결과병진행통계분석。결과：랑창성신염환자적ESR、CRP、IgG、IgM、IgA、C3급C4이상결과비솔분별위89.58%、58.33%、54.16%、6.25%、37.50%、50.00%급77.08%，이비랑창성신염SLE환자칙분별위72.58%、29.03%、38.71%、4.84%、33.87%、12.90%급17.74%,량조ESR、CRP、C3급C4적차이유통계학의의(P<0.05)；랑창성신염환자혈상규지표RBC、WBC、PLT급HGB이상결과비솔위31.25%、33.33%、29.16%급47.92%，비랑창성신염SLE환자칙분별위14.51%、11.29%、9.68%급18.87%,량조WBC화PLT적차이유통계학의의(P<0.05)；랑창성신염환자뇨상규지표BLO、PRO、LEU、RBC급WBC이상결과비솔위60.42%、41.67%、37.50%、43.75%급33.33%,비랑창성신염SLE환자칙분별위27.42%、3.23%、16.13%、24.19%급25.81%,량조BLO、PRO、LEU、RBC급WBC적차이유통계학의의(P<0.05)。결론：다항검험지표연합검측가위전신다계통손해제시신식，대계통성홍반랑창활동성판정유중요의의。
Objective:To study the application of evaluating the activity of systemic lupus erythematosus (SLE) with the combined detection of multi-indexes. Methods:Erythrocyte sedimentation rate were measured in 48 patients with lupus nephritis and 62 SLE patients with non-lupus nephritis by Westergerm assay. CRP, IgG, IgM, IgA, C3 and C4 were measured by AU5400 automated chemistry analyzer.Routine urine were measured by Mejer-600 automated urine chemistry analyzer and UF-1000i fully automated urine particle analyzer.Blood routine were detected by XT-1800i automated hematology analyzer. The results were analyzed statistically.Results:The abnormal result rates of ESR , CRP, IgG, IgM, IgA, C3 and C4 were 89.58%、58.33%、54.16%、6.25%、37.50%、50.00% and 77.08% in the patients with lupus nephritis, while those were 72.58%、29.03%、38.71%、4.84%、33.87%、12.90% and 17.74% in the SLE patients with non-lupus nephritis. Difference of two groups in ESR、CRP、C3 and C4 is significative in statistically(P<0.05);At the same time, in the lupus nephritis patients, the abnormal result rates of RBC, WBC, PLT and HGB in blood routine were 31.25%、33.33%、29.16% and 47.92%, those were 14.51%、11.29%、9.68% and 18.87% in blood routine in the SLE patients with non-lupus nephritis. Difference of two groups in WBC and PLT is significative in statistically(P<0.05);In routine urine the abnormal result rates of BLO、PRO、LEU、RBC and WBC were 60.42%、41.67%、37.50%、43.75% and 33.33%in the patients with lupus nephritis,those were 27.42%、3.23% 、16.13%、24.19% and 25.81% in the SLE patients with non-lupus nephritis. Difference of two groups in BLO、PRO、LEU、RBC and WBC is significative in statistically(P<0.05). Conclusions:The combined detection of multi-indexes can prompt the multi-system damage of the body, which is significant to determine the activity of systemic lupus erythematosus(SLE).
