CAJ | 학술논문

VI型分泌系统（type VI secretion system，T6SS）具有转运效应蛋白分子到多种类型靶细胞的能力，广泛存在于革兰氏阴性菌，其结构复杂。当前T6SS结构模型表明其装置至少包含两个复合物：细胞膜跨膜相关装置和动态的噬菌体样结构。本文主要围绕T6SS分泌装置的结构、结构元件相互作用功能以及影响装置表达和活性的条件和信号来进行简要综述。
VI형분비계통（type VI secretion system，T6SS）구유전운효응단백분자도다충류형파세포적능력，엄범존재우혁란씨음성균，기결구복잡。당전T6SS결구모형표명기장치지소포함량개복합물：세포막과막상관장치화동태적서균체양결구。본문주요위요T6SS분비장치적결구、결구원건상호작용공능이급영향장치표체화활성적조건화신호래진행간요종술。
Type VI secretion system (T6SS) widely exists in gram-negative bacteria and translocates protein effectors into a variety of target cell types. Current structural model of the T6SS indicates that the apparatus is composed of at least two complexes, a cell envelope spanning membrane-associated assembly and a dynamic bacteriophage-like structure. This review summarizes recent progress in T6SS structure, interaction of these elements to promote effector secretion and regulation on contact-dependent pathways of specific cellular targets.