CAJ | 학술논문

同源异型盒（HOX）蛋白质是高度保守的转录因子，决定着包括人类在内的许多物种的部分生物性状的表达。 HOXA10基因通过调节下游基因及雌激素、孕激素的表达直接影响子宫的胚胎发育和着床。根据体内激素的调控作用，HOXA10基因在子宫内膜上呈周期性表达，其表达高峰发生在植入窗期。HOXA10基因在子宫内膜异位症（EMs）病变中表达对子宫内膜组织的“从头开始”发育过程是必要的。EMs患者的子宫内膜存在影响胚胎着床的诸多不利因素，提示胚胎着床失败可能是EMs患者不孕的主要因素之一。EMs患者通常不会出现HOXA10表达水平在黄体中期上升的现象，可以解释EMs是造成不孕的原因之一。
동원이형합（HOX）단백질시고도보수적전록인자，결정착포괄인류재내적허다물충적부분생물성상적표체。 HOXA10기인통과조절하유기인급자격소、잉격소적표체직접영향자궁적배태발육화착상。근거체내격소적조공작용，HOXA10기인재자궁내막상정주기성표체，기표체고봉발생재식입창기。HOXA10기인재자궁내막이위증（EMs）병변중표체대자궁내막조직적“종두개시”발육과정시필요적。EMs환자적자궁내막존재영향배태착상적제다불리인소，제시배태착상실패가능시EMs환자불잉적주요인소지일。EMs환자통상불회출현HOXA10표체수평재황체중기상승적현상，가이해석EMs시조성불잉적원인지일。
The homebox (HOX) proteins, as the highly conserved transcription factors, determine some body characteristics in many species,including human. HOXA10 is directly involved in the embryogenesis and embryo implantation in uterus by regulating the downstream genes, and estrogen and progesterone levels. In accord with hormones regulation, expression of HOXA10 gene in endometrium has a periodic profile, with the peak expression during the implantation window. Expression of HOXA10 gene in ectopic endometrium is one of important factors related with the “de novo” development of endometrial tissue. There are many factors, which influence embryo implantation, in ectopic endometrium of patients with endometriosis(EMs). It is well known that the embryo implantation failure is one of the main factors of infertility in EMs patients. EMs patients usually do not have the increased expression of HOXA10 in mid-luteal stage, which is one of the reasons of infertility.