CAJ | 학술논문

人胚胎干细胞是人体内最原始的细胞，具有自我更新和分化为各种细胞的潜能，而信号通路在细胞的形态和功能变化中起着重要的协调和控制作用。目前的研究已经证实，Wnt信号通路在女性生殖系统的发育中起着重要的作用，是其分化形成的关键因子，在胚胎干细胞定向分化为子宫内膜样细胞的过程中，Wnt信号通路同样起着关键的调控作用。综述Wnt信号通路在人胚胎干细胞向子宫内膜样细胞分化过程中所起的作用，并展望今后对其的研究方向。
인배태간세포시인체내최원시적세포，구유자아경신화분화위각충세포적잠능，이신호통로재세포적형태화공능변화중기착중요적협조화공제작용。목전적연구이경증실，Wnt신호통로재녀성생식계통적발육중기착중요적작용，시기분화형성적관건인자，재배태간세포정향분화위자궁내막양세포적과정중，Wnt신호통로동양기착관건적조공작용。종술Wnt신호통로재인배태간세포향자궁내막양세포분화과정중소기적작용，병전망금후대기적연구방향。
Human embryonic stem cells (hESCs) are the most primitive cells with the potential for self-renewal and differentiation of various cell. The signaling pathways play important roles in regulating cellular morphology and function. Present study confirmed that the Wnt signaling pathway, as one of the key factors of differentiation, played an important role in regulating the development of female reproductive system. This pathway plays same key role during the differentiation of endometrial-like cells from embryonic stem cell. This review is about the Wnt signaling pathway in hESCs differentiation to endometrial cells,and the future research.