国际生殖健康计划生育杂志201306
國際生殖健康計劃生育雜誌201306
국제생식건강계화생육잡지201306
Journal of International Reproductive Health/Family Planning
2013年
6期
471-474,489
,共5页
覃茜(综述)%刘冬娥(审校)
覃茜(綜述)%劉鼕娥(審校)
담천(종술)%류동아(심교)
PTEN磷酸水解酶%基因%女(雌)性泌尿生殖系统疾病%卵泡%子宫内膜%胚胎发育
PTEN燐痠水解酶%基因%女(雌)性泌尿生殖繫統疾病%卵泡%子宮內膜%胚胎髮育
PTEN린산수해매%기인%녀(자)성비뇨생식계통질병%란포%자궁내막%배태발육
PTEN phosphohydrolase%Genes%Female urogenital diseases%Ovarian follicle%Endometrium%Embryonic development
近年来研究发现,抑癌基因Pten及其编码的PTEN蛋白可能通过磷脂酰肌醇3激酶(PI3K)等通路调控细胞的生长、分化及凋亡。在女性生殖系统中,PTEN通过PTEN-PI3K-3-磷酸肌醇依赖性蛋白激酶-1(PDK1)信号网络,不但控制原始卵泡的生存和激活、颗粒细胞的增殖和分化,影响卵泡的发育、生殖衰老的过程和生殖时间的长短,而且调控子宫内膜的增殖及早期胚胎的着床和发育。
近年來研究髮現,抑癌基因Pten及其編碼的PTEN蛋白可能通過燐脂酰肌醇3激酶(PI3K)等通路調控細胞的生長、分化及凋亡。在女性生殖繫統中,PTEN通過PTEN-PI3K-3-燐痠肌醇依賴性蛋白激酶-1(PDK1)信號網絡,不但控製原始卵泡的生存和激活、顆粒細胞的增殖和分化,影響卵泡的髮育、生殖衰老的過程和生殖時間的長短,而且調控子宮內膜的增殖及早期胚胎的著床和髮育。
근년래연구발현,억암기인Pten급기편마적PTEN단백가능통과린지선기순3격매(PI3K)등통로조공세포적생장、분화급조망。재녀성생식계통중,PTEN통과PTEN-PI3K-3-린산기순의뢰성단백격매-1(PDK1)신호망락,불단공제원시란포적생존화격활、과립세포적증식화분화,영향란포적발육、생식쇠로적과정화생식시간적장단,이차조공자궁내막적증식급조기배태적착상화발육。
Recent studies found that Pten, a tumor suppressor gene, and PTEN protein played an important role in regulating cell growth, differentiation and apoptosis through the PI3K pathway. In the female reproductive system, PTEN plays an important role in regulating follicular development, reproductive aging and years by controlling the survival and activation of primordial follicles , the proliferation and differentiation of granulosa cells though the PTEN-PI3K-PDK1 signaling networks. By the same networks, PTEN regulates the endometrial proliferation, and the implantation and development of early embryo.