CAJ | 학술논문

提高辅助生殖技术（ART）成功率和安全性是目前ART面临的重要课题。线粒体是卵母细胞/胚胎中数量最多的细胞器，不仅为卵母细胞的成熟、受精以及随后的胚胎发育过程中的转录与翻译提供能量，还与卵母细胞激活、钙振荡、凋亡程序启动等生命过程密切相关，而且胚胎中的线粒体全部来源于卵母细胞。线粒体功能的损伤也与卵母细胞老化、受精率及胚胎质量降低等密切相关。近年关于人和动物卵母细胞线粒体与ART的研究阐述了线粒体在卵母细胞成熟、受精以及胚胎发育过程中的作用、各种ART手段对卵母细胞线粒体功能的影响以及可能的线粒体保护手段。
제고보조생식기술（ART）성공솔화안전성시목전ART면림적중요과제。선립체시란모세포/배태중수량최다적세포기，불부위란모세포적성숙、수정이급수후적배태발육과정중적전록여번역제공능량，환여란모세포격활、개진탕、조망정서계동등생명과정밀절상관，이차배태중적선립체전부래원우란모세포。선립체공능적손상야여란모세포노화、수정솔급배태질량강저등밀절상관。근년관우인화동물란모세포선립체여ART적연구천술료선립체재란모세포성숙、수정이급배태발육과정중적작용、각충ART수단대란모세포선립체공능적영향이급가능적선립체보호수단。
It is important issue for assisted reproductive techniques(ART) to improve the pregnancy rate and security. As the most abundant organelles in oocytes,mitochondria not only take part in the energy supply for oocyte maturation, fertilization,transcription and translation during embryonic development,but also play roles in some key procedures such as the oocyte activation,calcium oscillation,and apoptosis. More importantly,all mitochondria in embryo were originated from oocyte,not the sperm. It has been demonstrated that mitochondria dysfunction is closely related to oocyte aging,low fertilization rate,poor embryo quality,and developmental arrest of embryo,etc. In this paper,the roles of mitochondrial function in oocyte maturation,fertilization and embryo development, as well as how to protect oocyte mitochondria and how to improve the function of oocyte mitochondria during ART, were reviewed.