国际生殖健康计划生育杂志201306
國際生殖健康計劃生育雜誌201306
국제생식건강계화생육잡지201306
Journal of International Reproductive Health/Family Planning
2013年
6期
454-458
,共5页
刘明(综述)%吉蕾(综述)%王雁玲(审校)
劉明(綜述)%吉蕾(綜述)%王雁玲(審校)
류명(종술)%길뢰(종술)%왕안령(심교)
先兆子痫%胎盘%生长障碍%微RNAs
先兆子癇%胎盤%生長障礙%微RNAs
선조자간%태반%생장장애%미RNAs
Pre-eclampsia%Placenta%Growth disorders%MicroRNAs
子痫前期(PE)是孕产妇死亡的主要原因之一,发病机制尚不明确,胎盘滋养层细胞发育障碍是其主要病因。妊娠过程中,胎盘功能不足可导致母胎界面氧化应激增高,促使胎盘过度分泌多种可溶性分子进入母体循环,诱导母体产生PE症状。胎盘合成的多种激素和因子,如血管生成因子及抗血管生成因子、2-甲氧雌二醇、心房利尿钠肽、激活素A和抑制素A,可部分反映PE胎盘的发育缺陷。近年研究发现, miRNAs和遗传因素与子痫前期发病相关。
子癇前期(PE)是孕產婦死亡的主要原因之一,髮病機製尚不明確,胎盤滋養層細胞髮育障礙是其主要病因。妊娠過程中,胎盤功能不足可導緻母胎界麵氧化應激增高,促使胎盤過度分泌多種可溶性分子進入母體循環,誘導母體產生PE癥狀。胎盤閤成的多種激素和因子,如血管生成因子及抗血管生成因子、2-甲氧雌二醇、心房利尿鈉肽、激活素A和抑製素A,可部分反映PE胎盤的髮育缺陷。近年研究髮現, miRNAs和遺傳因素與子癇前期髮病相關。
자간전기(PE)시잉산부사망적주요원인지일,발병궤제상불명학,태반자양층세포발육장애시기주요병인。임신과정중,태반공능불족가도치모태계면양화응격증고,촉사태반과도분비다충가용성분자진입모체순배,유도모체산생PE증상。태반합성적다충격소화인자,여혈관생성인자급항혈관생성인자、2-갑양자이순、심방이뇨납태、격활소A화억제소A,가부분반영PE태반적발육결함。근년연구발현, miRNAs화유전인소여자간전기발병상관。
Preeclampsia (PE) is one of the main causes for the death of pregnant women. The developmental disorders of placental trophoblastic cells are related to the pathogenesis of PE. The malfunction of placenta may result in a high oxidative stress at the feto-maternal interface,which stimulates the excessive production of various factors from placenta. Those soluble placental factors are released into maternal circulation ,eventually leading to the maternal symptoms of PE. Those hormones and molecules secreted by placenta, such as VEGF and anti-VEGF, methoxyestradiol, atrial natriuretic peptide, activin A and inhibin A, could partly reflect the developmental disorders of placenta. miRNAs and genetics were also found to be related to the pathogenesis of PE.