CAJ | 학술논문

环孢素A（CsA）是一种强效免疫抑制剂，在临床上被广泛应用于防治器官移植后排斥反应和治疗某些自身免疫性疾病。体外研究发现，低浓度CsA既能促进滋养细胞增殖、减少滋养细胞凋亡，也能增强滋养细胞的迁移与侵袭。体内研究发现，低剂量CsA可明显降低自然流产模型小鼠的胚胎吸收率，改善妊娠结局。这些研究结果提示，低剂量CsA对滋养细胞的生物学行为具有良性调节作用，有可能成为防治自然流产、子痫前期等滋养细胞功能异常导致的妊娠相关疾病的一种新策略。
배포소A（CsA）시일충강효면역억제제，재림상상피엄범응용우방치기관이식후배척반응화치료모사자신면역성질병。체외연구발현，저농도CsA기능촉진자양세포증식、감소자양세포조망，야능증강자양세포적천이여침습。체내연구발현，저제량CsA가명현강저자연유산모형소서적배태흡수솔，개선임신결국。저사연구결과제시，저제량CsA대자양세포적생물학행위구유량성조절작용，유가능성위방치자연유산、자간전기등자양세포공능이상도치적임신상관질병적일충신책략。
Cyclosporin A (CsA),one of the most powerful immunosuppressant,has been widely used to prevent organ rejection and treat certain autoimmune diseases. CsA at low concentrations can increase the proliferation and reduce the apoptosis of trophoblast cells,as well as promote the trophoblastic migration and invasion in vitro. The study in vivo has showed that administration with low dose CsA at the early stage of pregnancy can reduce fetal resorption rate and improve the pregnancy outcome in murine abortion-prone CBA/J × DBA/2 matings. These results above suggest that CsA appears to have favorable effect on the biological behaviors of trophoblast cell,and might be used as a unique therapeutics for miscarriage,preeclampsia,and other pregnancy-related diseases caused by trophoblast cell dysfunction.