CAJ | 학술논문

目的：探讨急性脑梗死合并2型糖尿病患者脑动脉微栓子与血清基质金属蛋白酶-9含量的关系。方法前瞻性地纳入颈动脉系统急性脑梗死患者118例，分为糖尿病急性脑梗死组60例、非糖尿病急性脑梗死组58例。收集一般临床资料，采用EMS-9型经颅多普勒超声检测仪及酶联免疫吸附测定法（ELISA）分别检测所有入组患者大脑中动脉微栓子信号及血清基质金属蛋白酶-9浓度，并进行相关分析。结果糖尿病并急性脑梗死患者微栓子信号阳性率高于非糖尿病急性脑梗死患者（P＜0.05）；糖尿病并急性脑梗死患者的血清基质金属蛋白酶-9含量明显高于非糖尿病急性脑梗死患者（P＜0.01）； Logistic回归提示，血清基质金属蛋白酶-9是微栓子信号阳性的危险因素（OR＝1.013，P＜0.01）。结论糖尿病并急性脑梗死患者微栓子信号阳性率与血清基质金属蛋白酶-9含量更高，基质金属蛋白酶-9的高表达可能促进微栓子的产生。
목적：탐토급성뇌경사합병2형당뇨병환자뇌동맥미전자여혈청기질금속단백매-9함량적관계。방법전첨성지납입경동맥계통급성뇌경사환자118례，분위당뇨병급성뇌경사조60례、비당뇨병급성뇌경사조58례。수집일반림상자료，채용EMS-9형경로다보륵초성검측의급매련면역흡부측정법（ELISA）분별검측소유입조환자대뇌중동맥미전자신호급혈청기질금속단백매-9농도，병진행상관분석。결과당뇨병병급성뇌경사환자미전자신호양성솔고우비당뇨병급성뇌경사환자（P＜0.05）；당뇨병병급성뇌경사환자적혈청기질금속단백매-9함량명현고우비당뇨병급성뇌경사환자（P＜0.01）； Logistic회귀제시，혈청기질금속단백매-9시미전자신호양성적위험인소（OR＝1.013，P＜0.01）。결론당뇨병병급성뇌경사환자미전자신호양성솔여혈청기질금속단백매-9함량경고，기질금속단백매-9적고표체가능촉진미전자적산생。
Objective To investigate the relationship between serum matrix metalloproteinase-9 (MMP-9) levels and transcranial Doppler (TCD)-detected microemboli in patients of acute cerebral infarction patients with type 2 diabetes. Methods The qualified 118 cases of acute cerebral infarction of carotid artery system in the study were included, 60 cases of acute cerebral infarction with type 2 diabetes and 58 cases of acute cerebral infarction with non diabetes-mellitus. General clinical data were collected. The serum MMP-9 levels were quantified by ELISA and the microemboli signal(MES)were detected with TCD in the 2 groups, and statistical analysis and statistical comparisons were done. Results The micro-emboli positive rate was higher in acute cerebral infarction patients with type 2 diabetes than that in acute cerebral infarction ones with non diabetes-mellitus(P<0.05); The level of serum MMP-9 was significantly higher in acute cerebral infarction patients with type 2 diabetes than that in cerebral infarction ones with non diabetes-mellitus(P<0.01);Logistic regression analysis showed that MMP-9 level was a risk factor of MES(OR=1.013, P<0.01) in acute cerebral infarction patients. Conclusion The micro-emboli positive rate and the level of serum MMP-9 are higher in patients of acute cerebral infarction with type 2 diabetics, the rise of serum MMP-9 level can result in microemboli.