医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2013年
9期
1757-1759
,共3页
消化不良%药物疗法
消化不良%藥物療法
소화불량%약물요법
Dyspepsia%DT
[目的]探讨黛力新联合曲美布丁、雷贝拉唑治疗功能性消化不良的疗效。[方法]符合罗马Ⅲ功能性消化不良诊断标准的伴有焦虑及抑郁状态的患者120例随机分为观察组60例和对照组60例。对照组根据个体化原则给予促动力药物＋促消化药物（马来酸曲美布丁＋复方阿嗪米特）和（或）质子泵抑制剂（雷贝拉唑），观察组在对照组的基础上加用黛力新联合治疗。两组疗程均4周。每例患者在治疗前后均详细填写临床疗效观察表及汉密尔顿抑郁量表（HAMD）和汉密尔顿焦虑量表（HAMA），并计算总有效率。[结果]观察组治疗后症状积分（1．80±0．91）分、HAMD 积分（13．45±4．24）分和 HAMA 积分（11．25±2．14）分，下降均较对照组[分别为（5．52±1．40）分，（20．52±6．40）分，（18．72±4．30）分]更明显（P ＜0．05）。对照组治疗总有效率73．33％；观察组治疗总有效率93．33％，二者有统计学差异（P ＜0．05）。[结论]黛力新联合曲美布丁、雷贝拉唑，可显著提高治疗功能性消化不良的疗效，不良反应少，可在临床应用推广。
[目的]探討黛力新聯閤麯美佈丁、雷貝拉唑治療功能性消化不良的療效。[方法]符閤囉馬Ⅲ功能性消化不良診斷標準的伴有焦慮及抑鬱狀態的患者120例隨機分為觀察組60例和對照組60例。對照組根據箇體化原則給予促動力藥物＋促消化藥物（馬來痠麯美佈丁＋複方阿嗪米特）和（或）質子泵抑製劑（雷貝拉唑），觀察組在對照組的基礎上加用黛力新聯閤治療。兩組療程均4週。每例患者在治療前後均詳細填寫臨床療效觀察錶及漢密爾頓抑鬱量錶（HAMD）和漢密爾頓焦慮量錶（HAMA），併計算總有效率。[結果]觀察組治療後癥狀積分（1．80±0．91）分、HAMD 積分（13．45±4．24）分和 HAMA 積分（11．25±2．14）分，下降均較對照組[分彆為（5．52±1．40）分，（20．52±6．40）分，（18．72±4．30）分]更明顯（P ＜0．05）。對照組治療總有效率73．33％；觀察組治療總有效率93．33％，二者有統計學差異（P ＜0．05）。[結論]黛力新聯閤麯美佈丁、雷貝拉唑，可顯著提高治療功能性消化不良的療效，不良反應少，可在臨床應用推廣。
[목적]탐토대력신연합곡미포정、뢰패랍서치료공능성소화불량적료효。[방법]부합라마Ⅲ공능성소화불량진단표준적반유초필급억욱상태적환자120례수궤분위관찰조60례화대조조60례。대조조근거개체화원칙급여촉동력약물＋촉소화약물（마래산곡미포정＋복방아진미특）화（혹）질자빙억제제（뢰패랍서），관찰조재대조조적기출상가용대력신연합치료。량조료정균4주。매례환자재치료전후균상세전사림상료효관찰표급한밀이돈억욱량표（HAMD）화한밀이돈초필량표（HAMA），병계산총유효솔。[결과]관찰조치료후증상적분（1．80±0．91）분、HAMD 적분（13．45±4．24）분화 HAMA 적분（11．25±2．14）분，하강균교대조조[분별위（5．52±1．40）분，（20．52±6．40）분，（18．72±4．30）분]경명현（P ＜0．05）。대조조치료총유효솔73．33％；관찰조치료총유효솔93．33％，이자유통계학차이（P ＜0．05）。[결론]대력신연합곡미포정、뢰패랍서，가현저제고치료공능성소화불량적료효，불량반응소，가재림상응용추엄。
[Objective]To observe the efficacy of the combination with Deanxit for the treatment of func-tional dyspepsia.[Methods]Totally 120 patients with functional dyspepsia according with Rome III diagnostic standard and anxious as well as depressive state were randomly divided into treatment group(n=60)and con-trol group(n=60).According to the principle of individualization,the control group was treated with proki-netic drug,digestion drug(trimebutine maleate and compound azintamide)and/or proton pump inhibitor(rabe-prazole),while the treatment group was additionally treated with Deanxit based on the treatment of the control group.Both groups were treated for 4 weeks.Each patient filled clinical curative effect observation table, Hamilton depression scale(HAMD)and Hamilton anxiety scale(HAMA)before and after treatment.Total ef-fective rate was calculated.[Results]Compared with control group,the symptom score,HAMD and HAMA scores in treatment group after treatment decreased more significantly[(1.80 ± 0.91)vs (5.52 ± 1.40), (13.45±4.24)vs (20.52±6.40),(11.25±2.14)vs (18.72±4.30)](P <0.05).The overall effective rate of control group and treatment group was 73.33% and 93.33% respectively,and there was significant differ-ence(P < 0.05).[Conclusion]Compared with single use of prokinetic drug,digestion drug and/or proton pump inhibitor,the combination of Deanxit for the treatment of functional dyspepsia can significantly improve the efficacy with less adverse reaction,so it can be recommended to use in clinical practice.
