医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2013年
9期
1707-1710
,共4页
心肌疾病%药物疗法
心肌疾病%藥物療法
심기질병%약물요법
Cardiomyopathies%DT
[目的]探讨左卡尼汀对儿童心肌病患者心功能的影响。[方法]本院收治的88例心肌病患者随机分为试验组和对照组，对照组给予常规治疗，试验组在对照组治疗基础上缓慢静脉注射左卡尼汀100 mg/（kg·d），疗程14 d，后改为左卡尼汀口服，6岁以下10 mL/d（1．0 g/10 mL），7岁以上每次10 mL，1日2次。观察两组患者治疗前后心功能改善情况及心电图、血 C 反应蛋白（CRP）、心肌酶的变化并进行比较。[结果]治疗后试验组和对照组患者左室射血分数（LVEF）、心排出量（CO）、每搏输出量（SV）、心指数（CI）及左心舒张功能指标：EF 斜率（MVEF）和左室后壁运动快充盈期分数（LFFPW）较治疗前明显提高；血 CRP、心肌酶较治疗前明显下降，且差异有显著性（P ＜0．05）。且试验组较对照组改善更明显，两组相比较差异有显著性（P ＜0．05）。[结论]左卡尼汀可以改善儿童心肌病患者心功能，且疗效显著。
[目的]探討左卡尼汀對兒童心肌病患者心功能的影響。[方法]本院收治的88例心肌病患者隨機分為試驗組和對照組，對照組給予常規治療，試驗組在對照組治療基礎上緩慢靜脈註射左卡尼汀100 mg/（kg·d），療程14 d，後改為左卡尼汀口服，6歲以下10 mL/d（1．0 g/10 mL），7歲以上每次10 mL，1日2次。觀察兩組患者治療前後心功能改善情況及心電圖、血 C 反應蛋白（CRP）、心肌酶的變化併進行比較。[結果]治療後試驗組和對照組患者左室射血分數（LVEF）、心排齣量（CO）、每搏輸齣量（SV）、心指數（CI）及左心舒張功能指標：EF 斜率（MVEF）和左室後壁運動快充盈期分數（LFFPW）較治療前明顯提高；血 CRP、心肌酶較治療前明顯下降，且差異有顯著性（P ＜0．05）。且試驗組較對照組改善更明顯，兩組相比較差異有顯著性（P ＜0．05）。[結論]左卡尼汀可以改善兒童心肌病患者心功能，且療效顯著。
[목적]탐토좌잡니정대인동심기병환자심공능적영향。[방법]본원수치적88례심기병환자수궤분위시험조화대조조，대조조급여상규치료，시험조재대조조치료기출상완만정맥주사좌잡니정100 mg/（kg·d），료정14 d，후개위좌잡니정구복，6세이하10 mL/d（1．0 g/10 mL），7세이상매차10 mL，1일2차。관찰량조환자치료전후심공능개선정황급심전도、혈 C 반응단백（CRP）、심기매적변화병진행비교。[결과]치료후시험조화대조조환자좌실사혈분수（LVEF）、심배출량（CO）、매박수출량（SV）、심지수（CI）급좌심서장공능지표：EF 사솔（MVEF）화좌실후벽운동쾌충영기분수（LFFPW）교치료전명현제고；혈 CRP、심기매교치료전명현하강，차차이유현저성（P ＜0．05）。차시험조교대조조개선경명현，량조상비교차이유현저성（P ＜0．05）。[결론]좌잡니정가이개선인동심기병환자심공능，차료효현저。
[Objective]To explore the effect of levocarnitine on cardiac function of pediatric patients with cardiomyopathy.[Methods]A total of 88 patients with myocardiopathy were randomly divided into treatment group and control group.The control group received conventional therapy.Based on the treatment of control group,the treatment group received intravenous injection with levocarnitine 100mg/kg.d for 14 days,and then changed to oral levocarnitine consistently.The oral dosage was 10mL(1.0g/10mL)once a day in patients un-der 6 years old and 10ml twice a day in patients older than 7 years old.The improvement of cardiac function, electrocardiography and the changes of C-reactive protein(CRP)and myocardial enzymes before and after treat-ment were observed.Electrocardiography,blood CRP and myocardial enzymes were compared.[Results]Compared with before treatment,left ventricular ejection fraction(LVEF),cardiac output(CO),stroke vol-ume(SV),cardiac index(CI)and left cardiac diastolic function indexes such as EF slope(MVEF)and left ven-tricular wall motion fast filling phase fraction(LFFPW)obviously increased after treatment.Compared with before treatment,blood CRP and myocardial enzymes obviously decreased after treatment,and there were sig-nificant differences(P <0.05).The improvement of treatment group was more obvious than that of control group,and there was significant difference(P <0.05).[Conclusion]Levocarnitine can improve cardiac func-tion in pediatric patients with cardiomyopathy.Levocarnitine for the treatment of pediatric patients with car-diomyopathy can achieve good efficacy.L-carnitine has a good therapeutic effect in pediatric patients with car-diomyopathy.
