CAJ | 학술논문

[目的]探讨原发干燥综合征（pSS）伴肺间质疾病（ILD）患者的临床表现、肺部高分辨率 CT （HRCT）及实验室指标的特点。[方法]收集 pSS 患者193例，依据 HRCT 结果判断是否合并 ILD，分为单纯pSS 组和 pSS-ILD 组，比较两组的临床特点。[结果]pSS-ILD 组患者年龄、发病年龄及病程均显著高于单纯pSS 组（P ＜0．01）；pSS-ILD 组患者咳嗽发生率、抗心磷脂抗体（ACLA）的阳性率明显高于单纯 pSS 组（P ＜0．05）；pSS-ILD 组患者的γ-G 百分率、IgG、纤维蛋白原（Fg）、C 反应蛋白（CRP）、血沉（ESR）的水平均高于单纯 pSS 组（P ＜0．05），而血清白蛋白（Alb）水平低于单纯 pSS 组（P ＜0．05）。[结论]年龄较大的 pSS 患者易伴发 ILD，pSS 患者中若伴有咳嗽症状需警惕是否伴有 ILD；ACLA，γ-G 百分率及 IgG、补体 C3、Alb、CRP、ESR、Fg 水平可作为预测 pSS 伴发 ILD 的临床指标。
[목적]탐토원발간조종합정（pSS）반폐간질질병（ILD）환자적림상표현、폐부고분변솔 CT （HRCT）급실험실지표적특점。[방법]수집 pSS 환자193례，의거 HRCT 결과판단시부합병 ILD，분위단순pSS 조화 pSS-ILD 조，비교량조적림상특점。[결과]pSS-ILD 조환자년령、발병년령급병정균현저고우단순pSS 조（P ＜0．01）；pSS-ILD 조환자해수발생솔、항심린지항체（ACLA）적양성솔명현고우단순 pSS 조（P ＜0．05）；pSS-ILD 조환자적γ-G 백분솔、IgG、섬유단백원（Fg）、C 반응단백（CRP）、혈침（ESR）적수평균고우단순 pSS 조（P ＜0．05），이혈청백단백（Alb）수평저우단순 pSS 조（P ＜0．05）。[결론]년령교대적 pSS 환자역반발 ILD，pSS 환자중약반유해수증상수경척시부반유 ILD；ACLA，γ-G 백분솔급 IgG、보체 C3、Alb、CRP、ESR、Fg 수평가작위예측 pSS 반발 ILD 적림상지표。
[Objective]To explore the clinical manifestation and the features of pulmonary HRCT and labo-ratory indices of primary Sjogren syndrome(pSS)with interstitial lung disease(ILD).[Methods]Totally 193 patients with pSS were collected.Based on the results of HRCT,pSS with or without ILD was judged.All patients were divided into simple pSS group and pSS-ILD group.Clinical features were compared between two groups.[Results]The age,onset age and disease duration in pSS-ILD group were higher than those in simple pSS group(P < 0.01).The incidence of cough and the positive rate of anticardiolipin antibody(ACLA)in pSS-ILD group were higher than those in simple pSS group(P <0.05).The levels of IgG,γ-G,fibrinogen (Fg),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)in pSS-ILD group were higher than those in simple pSS group(P <0.05),while the levels of serum albumin(Alb)in pSS-ILD group were lower than those in simple pSS group(P <0.05).[Conclusion]The elder patients with pSS are prone to accompany with ILD.The patients with pSS who have cough should be alerted to have ILD.ACLA,the percentage ofγ-G and the levels of IgG,C3,Alb CRP,ESR and Fg can be used as the clinical indices to predict the occurrence of ILD in pSS patients.