CAJ | 학술논문

目的：研究80岁以上高血压患者合并高脂血症对颈动脉内中膜厚度的影响。方法从体检人群中收集高血压合并高脂血症患者52例作为研究组，按性别、年龄、血压匹配随机抽取单纯高血压患者38例作为对照组。收集年龄、高血压病程、收缩压、舒张压、血糖、甘油三酯、低密度脂蛋白、高密度脂蛋白、总胆固醇、颈动脉内中膜厚度等指标，比较两组间各指标的差异，P <0.05作为有统计学差异。结果两组之间年龄、病程、血糖、收缩压、舒张压差异无统计学意义(P＞0.05)。高血压合并高脂血症组 TG、TC、LDLC 及 HDLC 与单纯高血压组差异具有显著性，高血压合并高脂血症组大于单纯高血压组(P <0.05)。单纯高血压组和高血压合并高脂血症组颈动脉内中膜厚度差异具有显著性，高血压合并高脂血症颈动脉内中膜厚度(1.12±0.20mm)明显高于单纯高血压组(0.98±0.34mm)(t=2.448,P =0.016<0.05)。结论高血脂与颈动脉内中膜厚度正相关，高脂血症加速了高血压病患者的动脉硬化，应引起足够的重视。
목적：연구80세이상고혈압환자합병고지혈증대경동맥내중막후도적영향。방법종체검인군중수집고혈압합병고지혈증환자52례작위연구조，안성별、년령、혈압필배수궤추취단순고혈압환자38례작위대조조。수집년령、고혈압병정、수축압、서장압、혈당、감유삼지、저밀도지단백、고밀도지단백、총담고순、경동맥내중막후도등지표，비교량조간각지표적차이，P <0.05작위유통계학차이。결과량조지간년령、병정、혈당、수축압、서장압차이무통계학의의(P＞0.05)。고혈압합병고지혈증조 TG、TC、LDLC 급 HDLC 여단순고혈압조차이구유현저성，고혈압합병고지혈증조대우단순고혈압조(P <0.05)。단순고혈압조화고혈압합병고지혈증조경동맥내중막후도차이구유현저성，고혈압합병고지혈증경동맥내중막후도(1.12±0.20mm)명현고우단순고혈압조(0.98±0.34mm)(t=2.448,P =0.016<0.05)。결론고혈지여경동맥내중막후도정상관，고지혈증가속료고혈압병환자적동맥경화，응인기족구적중시。
Objective To study the effects of hyperlipidemia on carotid intima media thickness (CAIMT) in Hypertension patients at 80 years or elder. Methods 52 hypertension patients with hyperlipidemia were selected into the study group, while 38 hypertension patients with similar age and blood pressure history were selected into the control group. The data of age, clinical history, systolic blood pressure (SBP), diastolic blood pressure (DBP), blood sugar(BS), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol (LDLC), and CAIMT were collected and compared respectively between the two groups. Results No significant difference on sex, age, blood pressure, and BS were found between two groups (P<0.05); yet, it reflected significant difference between the two groups on TG, TC, HDLC and LDLC (P <0.05). The CAIMT (1.12±0.20mm) in the study group was significantly higher than that in hypertensive patients group (0.98 ± 0.34mm) (t=2.448, P =0.016< 0.05). Conclusion Lipids are relevant to CAIMT, and hyperlipidemia accelerated arteriosclerosis in the patients with hypertension at 80 years or elder.