中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2013年
11期
1770-1771,1773
,共3页
恶性白血病%去白细胞输血%免疫功能%临床研究
噁性白血病%去白細胞輸血%免疫功能%臨床研究
악성백혈병%거백세포수혈%면역공능%림상연구
Malignant leukemia%Blood transfusion%Immune function%Clinical research
目的：研究对恶性血液病患者输入去白细胞的血液后，患者的免疫功能影响。方法：我院选择206例恶性血液病患者，随机分为两组，对照组104例，输入常规的血液；观察组102例，输入去白细胞的血液。对这两组患者的NK细胞、T细胞亚群的活性以及红细胞C3b受体花环率进行比较。结果：两组患者输血前的NK细胞、T细胞亚群的活性以及红细胞C3b受体花环率等细胞免疫功能比较未见明显差异(P>0.05)。对照组患者输血前后T3、红细胞C3b受体花环率等细胞免疫功能指标差异较为显著，观察组患者输血前后T3、T4、T4/T8、NK细胞活性以及红细胞C3b受体花环率等指标差异较为显著，而且观察组患者的T4、T4/T8、NK细胞活性以及红细胞C3b受体花环率等指标和对照组相比，明显高于对照组(P<0.05)。结论：输入去白细胞的血液能够明显改善恶性血液病患者的细胞免疫功能。
目的：研究對噁性血液病患者輸入去白細胞的血液後，患者的免疫功能影響。方法：我院選擇206例噁性血液病患者，隨機分為兩組，對照組104例，輸入常規的血液；觀察組102例，輸入去白細胞的血液。對這兩組患者的NK細胞、T細胞亞群的活性以及紅細胞C3b受體花環率進行比較。結果：兩組患者輸血前的NK細胞、T細胞亞群的活性以及紅細胞C3b受體花環率等細胞免疫功能比較未見明顯差異(P>0.05)。對照組患者輸血前後T3、紅細胞C3b受體花環率等細胞免疫功能指標差異較為顯著，觀察組患者輸血前後T3、T4、T4/T8、NK細胞活性以及紅細胞C3b受體花環率等指標差異較為顯著，而且觀察組患者的T4、T4/T8、NK細胞活性以及紅細胞C3b受體花環率等指標和對照組相比，明顯高于對照組(P<0.05)。結論：輸入去白細胞的血液能夠明顯改善噁性血液病患者的細胞免疫功能。
목적：연구대악성혈액병환자수입거백세포적혈액후，환자적면역공능영향。방법：아원선택206례악성혈액병환자，수궤분위량조，대조조104례，수입상규적혈액；관찰조102례，수입거백세포적혈액。대저량조환자적NK세포、T세포아군적활성이급홍세포C3b수체화배솔진행비교。결과：량조환자수혈전적NK세포、T세포아군적활성이급홍세포C3b수체화배솔등세포면역공능비교미견명현차이(P>0.05)。대조조환자수혈전후T3、홍세포C3b수체화배솔등세포면역공능지표차이교위현저，관찰조환자수혈전후T3、T4、T4/T8、NK세포활성이급홍세포C3b수체화배솔등지표차이교위현저，이차관찰조환자적T4、T4/T8、NK세포활성이급홍세포C3b수체화배솔등지표화대조조상비，명현고우대조조(P<0.05)。결론：수입거백세포적혈액능구명현개선악성혈액병환자적세포면역공능。
Objective:To study the input for the patients with hematologic malignancies leukoreduced blood, affect the immune function of patients with. Methods:In our hospital 206 cases of malignant blood disease patients, which were randomly divided into two groups, including 104 patients as control group, these patients input routine blood, the other 102 cases as the observation group, the patients input leukoreduced blood. To compare the activity of the two groups of patients with NK cell, T cell subsets and erythrocyte C3b receptor rosette rate. Results:The activity of two groups of patients before blood transfusion in NK cell, T cell subsets and erythrocyte C3b receptor rosette rate and cellular immune function, no obvious difference, no statistical significance ( P>0.05 ). Different control parameters before and after T3, patients blood erythrocyte C3b receptor rosette rate and cellular immune function is more significant, difference observed groups before and after blood transfusion, T4 T3, T4/T8, NK cell activity and erythrocyte C3b receptor rosette rate was significant, but compared to the observation group of patients with T4, T4/T8, NK cell activity and red cell C3b receptor rosette rate and the control group, significantly higher than that in control group, compared the differences between the two groups was statistically significant(P<0.05). Conclusion:Compared to the observation group patients and patients in the control group, blood to white blood cells can obviously improve the cellular immune function in patients with malignant hematological diseases, and is worthy of popularizing in clinical use.
