CAJ | 학술논문

目的：研究醋酸(VIA)和碘(VILI)实验在经济欠发达地区的宫颈病变筛查的可行性。方法：选取岑溪市26～50岁的妇女1827名,进行两次宫颈癌筛查,第一次筛查采用5%的VIA实施染色以后用肉眼观察(VIA)和2%的VILI进行染色以后用肉眼观察(VILI),对症状异常的患者进行病毒学HPVDNA检测；第二次使用阴道镜活检,对症状异常的患者进行病毒学HPVDNA检测。对比两次筛查结果,评价VIA和VILI实验筛查宫颈癌效果。结果：第一次筛查中出现CINⅠ128例、CINⅡ113例、CINⅢ27例、宫颈癌9例,并通过使用病毒学HPVDNA检测诊断进行确认；一周后进行第二次筛查,采用阴道镜活检筛查出CINⅠ135例、CINⅡ121例、CINⅢ31例、宫颈癌10例,并通过使用病毒学HPVDNA检测诊断进行确认。VIA和VILI实验筛查方法与阴道镜活检方法的筛查效果差异不明显,不具有统计学意义(P<0.05),VIA和VILI实验筛查方法与阴道镜活检方法筛查结果接近；与历年筛查相比,癌前病变的检出率差别有统计学意义(P<0.05)；宫颈癌的检出率差别无统计学意义(P>0.05)结论：在经济欠发达地区,VIA和VILI方法对妇女进行开展宫颈癌和癌前病变的筛查效果不错,筛查出的阳性患者得到了及时治疗,对减少宫颈癌患者的死亡有一定促进作用。
목적：연구작산(VIA)화전(VILI)실험재경제흠발체지구적궁경병변사사적가행성。방법：선취잠계시26～50세적부녀1827명,진행량차궁경암사사,제일차사사채용5%적VIA실시염색이후용육안관찰(VIA)화2%적VILI진행염색이후용육안관찰(VILI),대증상이상적환자진행병독학HPVDNA검측；제이차사용음도경활검,대증상이상적환자진행병독학HPVDNA검측。대비량차사사결과,평개VIA화VILI실험사사궁경암효과。결과：제일차사사중출현CINⅠ128례、CINⅡ113례、CINⅢ27례、궁경암9례,병통과사용병독학HPVDNA검측진단진행학인；일주후진행제이차사사,채용음도경활검사사출CINⅠ135례、CINⅡ121례、CINⅢ31례、궁경암10례,병통과사용병독학HPVDNA검측진단진행학인。VIA화VILI실험사사방법여음도경활검방법적사사효과차이불명현,불구유통계학의의(P<0.05),VIA화VILI실험사사방법여음도경활검방법사사결과접근；여력년사사상비,암전병변적검출솔차별유통계학의의(P<0.05)；궁경암적검출솔차별무통계학의의(P>0.05)결론：재경제흠발체지구,VIA화VILI방법대부녀진행개전궁경암화암전병변적사사효과불착,사사출적양성환자득도료급시치료,대감소궁경암환자적사망유일정촉진작용。
Objective: To study of acetic acid(VIA) and iodine(VILI) experiment in underdeveloped areas the feasibility of screening for cervical lesions.Methods:Select Cenxi city women aged 26~50 in 1827, two of cervical cancer screening, the first screening using 5%VIA for dyeing later observed with the naked eye, VIA and 2%VILI staining VILI when observed with the naked eye, the symptoms in patients with abnormal HPVDNA detection for Virology;second the use of colposcopy with biopsy, the symptoms in patients with abnormal HPVDNA detection for virology. Comparison of two screening results, evaluate VIA and VILI test in cervical cancer screening effect.Results:First appeared in the screening of CINⅠin 128 cases, 113 cases of CINⅡ, CINⅢ27 cases, 9 cases of cervical cancer, and through the use of Virology diagnostic HPVDNA testing for confirmation;a week later for a second screening, using colposcopy with biopsy screen out CINⅠin 135 cases, 121 cases of CINⅡ, CINⅢ31 cases, cervical in 10 cases, and through the use of viral HPVDNA detection in the diagnosis of confirmation. VIA and VILI experiment method for screening and colposcopy biopsy method screening effect had no significant difference, the difference was not statistically significant(P<0.05), VIA and VILI experiment method for screening and colposcopy biopsy method for screening results quite. Compared with the calendar year, the screening difference of precancerous lesions detection rates was statistically significant(P<0.05);cervical cancer detection rate was no significant difference(P>0.05).Conclusion:Owe in economy develop area, VIA and VILI methods on women in cervical cancer and precancerous lesions of the screening effect is good, the screening of patients with positive got timely treatment for cervical carcinoma patients, reduce the death for a certain role.