CAJ | 학술논문

目的：评价前列腺素E1(PGE1)用于治疗冠心病(CHD)患者的效果及其对心率变异性(HRV)的影响。方法：将60例稳定型心绞痛患者随机分为观察组和常规组,常规组给予常规治疗,观察组在其基础上加注前列腺素E1,比较两组患者心脏自主神经病变症状改善情况、治疗前后24小时动态心电图HRV变化情况以及不良反应发生情况。结果：观察组总有效率略高于常规组(90%vs80%)；治疗后两组HRV时域指标均有所上升,但观察组治疗后增幅较常规组高(P<0.05)；常规组治疗后仅LF/HF较治疗前升高(P<0.05),观察组LF、HF和LF/HF均较治疗前显著升高(P<0.05),与常规组相比,观察组治疗后LF、HF和LF/HF增幅增加更显显著(P<0.05)；两组患者均未发生严重不良反应。结论：PGE1能有效改善CHD患者心脏自主神经病变症状及HRV水平,且安全性较高。
목적：평개전렬선소E1(PGE1)용우치료관심병(CHD)환자적효과급기대심솔변이성(HRV)적영향。방법：장60례은정형심교통환자수궤분위관찰조화상규조,상규조급여상규치료,관찰조재기기출상가주전렬선소E1,비교량조환자심장자주신경병변증상개선정황、치료전후24소시동태심전도HRV변화정황이급불량반응발생정황。결과：관찰조총유효솔략고우상규조(90%vs80%)；치료후량조HRV시역지표균유소상승,단관찰조치료후증폭교상규조고(P<0.05)；상규조치료후부LF/HF교치료전승고(P<0.05),관찰조LF、HF화LF/HF균교치료전현저승고(P<0.05),여상규조상비,관찰조치료후LF、HF화LF/HF증폭증가경현현저(P<0.05)；량조환자균미발생엄중불량반응。결론：PGE1능유효개선CHD환자심장자주신경병변증상급HRV수평,차안전성교고。
Objective:To evaluate the effect of prostaglandin E1 (PGE1) on patients with coronary heart disease(CHD) and its influence on heart rate variability(HRV). Methods:60 patients with stable angina were randomly assigned to observation group and control group. Regular treatment was put in both groups and PGE1 was added in observation group in addition. The improvement of cardiac autonomic nerve pathological change symptom, change of HRV in ambulatory electrocardiogram 24 hours before and after treatment, and adverse reaction incidence were compared between two groups. Results:The overall efficient of observation group was higher than control group(90%vs80%). The ascension of HRV time domain indice after treatment were observed in both groups while the increase of observation group was significantly higher than control group (P<0.05). LF/HF of control group was higher after treatment (P<0.05). LF, HF and LF/HF in observation group were significantly increased after treatment(P<0.05), and compared to control group, the increase of the 3 indice in observation group were significantly higher (P<0.05). No adverse reaction was observed in both groups. Conclusion:PGE1 could improve cardiac autonomic nerve pathological change symptom and HRV level of CHD patients effectively, with satisfactory safety.