CAJ | 학술논문

目的：研究Wnt信号通路抑制因子DKK1、分泌型卷曲相关蛋白（SFRP)4及Wnt基因家族因子（Wnt1）在宫颈鳞癌中的表达及其临床意义。方法76例宫颈癌患者病理标本为SCC组，36例子宫良性肿瘤切除标本为对照组（NC组），应用免疫组化法检测DKK1、SFRP4及Wnt1在SCC组及NC组中的表达。结果 DKK1在SCC组的表达低于NC组（P<0.05)。SFRP4及Wnt1在SCC组的表达均高于NC组（P<0.05)。DKK1、SFRP4及Wnt1在不同临床病理分期、组织分化程度、肿瘤大小及有无淋巴结转移SCC患者间表达差异有统计学意义（均P<0.05）。宫颈鳞癌中DKK1与SFRP4、Wnt1的表达均呈负相关（均P<0.05），SFRP4与Wnt1在宫颈鳞癌中的表达呈正相关（P<0.05）。结论 SFRP4和Wnt1在宫颈鳞癌的发生中可能存在协同作用，而DKK1可能作为宫颈鳞癌的抑制因子发挥作用。
목적：연구Wnt신호통로억제인자DKK1、분비형권곡상관단백（SFRP)4급Wnt기인가족인자（Wnt1）재궁경린암중적표체급기림상의의。방법76례궁경암환자병리표본위SCC조，36례자궁량성종류절제표본위대조조（NC조），응용면역조화법검측DKK1、SFRP4급Wnt1재SCC조급NC조중적표체。결과 DKK1재SCC조적표체저우NC조（P<0.05)。SFRP4급Wnt1재SCC조적표체균고우NC조（P<0.05)。DKK1、SFRP4급Wnt1재불동림상병리분기、조직분화정도、종류대소급유무림파결전이SCC환자간표체차이유통계학의의（균P<0.05）。궁경린암중DKK1여SFRP4、Wnt1적표체균정부상관（균P<0.05），SFRP4여Wnt1재궁경린암중적표체정정상관（P<0.05）。결론 SFRP4화Wnt1재궁경린암적발생중가능존재협동작용，이DKK1가능작위궁경린암적억제인자발휘작용。
Objective To investigate the expressions of DKK1,SFRP4 and Wnt1 in cervical squamous cell carcino-ma(SCC), and the clinical significance thereof. Methods There were 76 samples of cervical squamous cell carcinoma were included in SCC group and 36 benign uterine resection specimens were control group (NC). The immunohistochemical meth-od was applied to detect the expressions of DKK1,SFRP4 and Wnt1 in two groups. Results The expression of DKK1 was significantly lower in SCC group than that in NC group (P<0.05). The expression levels of SFRP4 and Wnt1 were significant-ly higher in SCC group than those of NC group (P<0.05). There were significant differences in the expressions of DKK1, SFRP4 and Wnt1 between samples of different clinical staging, differentiation, sizes of tumor and lymph node metastasis (P<0.05). The expression of DKK1 was negatively correlated with SFRP4 and Wnt1 in SCC group (P<0.05). The expression of SFRP4 was positively correlated with Wnt1 in SCC group (P<0.05). Conclusion The roles of SFRP4 and Wnt1 are syn-ergistic interactions in the development of SCC. DKK1 is an inhibiting factor of SCC.