CAJ | 학술논문

目的：探讨基质金属蛋白酶-3（MMP-3）启动子区域5A/6A基因多态性是否参与了经皮冠状动脉介入治疗（PCI）术后再狭窄发生发展过程。方法入选行PCI治疗术后复查的冠状动脉造影患者437例。收集患者复查冠状动脉造影前、后临床资料及造影结果，并留取血标本进行血清MMP-3含量以及基因多态性分析。根据MMP-3基因表型不同，分为突变组（5A/5A+5A/6A，n=136）和野生组（6A/6A，n=301）。比较2组相关资料，分析基因多态性与再狭窄的关系。结果2组再狭窄率差异无统计学意义（42.2%vs 33.1%，P＞0.05）。与突变组比较，野生组再狭窄程度[（56.28±11.10）%vs（36.00±10.17）%]较高（P＜0.01）；2组血清MMP-3含量[（13.38±3.00）μg/L vs（12.33±2.96）μg/L]差异无统计学意义（P＞0.05）。携带6A等位基因患者再狭窄率要高于携带5A等位基因患者（P＜0.05）。携带野生基因型是PCI术后再狭窄的危险因素。结论携带6A等位基因患者再狭窄风险性明显高于携带5A等位基因患者。
목적：탐토기질금속단백매-3（MMP-3）계동자구역5A/6A기인다태성시부삼여료경피관상동맥개입치료（PCI）술후재협착발생발전과정。방법입선행PCI치료술후복사적관상동맥조영환자437례。수집환자복사관상동맥조영전、후림상자료급조영결과，병류취혈표본진행혈청MMP-3함량이급기인다태성분석。근거MMP-3기인표형불동，분위돌변조（5A/5A+5A/6A，n=136）화야생조（6A/6A，n=301）。비교2조상관자료，분석기인다태성여재협착적관계。결과2조재협착솔차이무통계학의의（42.2%vs 33.1%，P＞0.05）。여돌변조비교，야생조재협착정도[（56.28±11.10）%vs（36.00±10.17）%]교고（P＜0.01）；2조혈청MMP-3함량[（13.38±3.00）μg/L vs（12.33±2.96）μg/L]차이무통계학의의（P＞0.05）。휴대6A등위기인환자재협착솔요고우휴대5A등위기인환자（P＜0.05）。휴대야생기인형시PCI술후재협착적위험인소。결론휴대6A등위기인환자재협착풍험성명현고우휴대5A등위기인환자。
Objective To investigate the relationship between matrix metalloproteinase-3 (MMP-3) gene promoter polymorphisms 5A/6A and the restenosis after percutaneous coronary intervention (PCI). Methods A total of 437 patients with PCI were selected in this study. Patients were divided into mutant genotype group (5A/5A+5A/6A, n=136) and wild genotype group (6A/6A, n=301) according to MMP-3 polymorphism. The angiography and clinic data were collected before and after coronary angiography in two groups of patients. The serum level MMP-3 and genotype analysis were compared be-tween two groups. Results There was no significant difference in the restenosis rate between two groups (42.2%vs 33.1%, P>0.05). The restenosis degree was significantly higher in wild genotype group than that in mutant genotype group (56.28%± 11.10%vs 36.00%±10.17%, P<0.01). There was no significant difference in the serum level of MMP-3 between two groups (13.38μg/L ± 3.00μg/L vs 12.33μg/L ± 2.96μg/L, P>0.05). There was a higher restenosis rate in patients carrying 6A al-lele than that of patients carrying 5A allele (P<0.05). Carrying wild genotypes are risk factors for restenosis after PCI. Con-clusion Patients carrying 6A allele have significantly higher risk of resteonsis than patients carrying 5A allele.