天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2013年
11期
1048-1051
,共4页
螺杆菌,幽门%疱疹病毒4型,人%胃肿瘤%癌%螺杆菌感染%爱泼斯坦巴尔病毒感染
螺桿菌,幽門%皰疹病毒4型,人%胃腫瘤%癌%螺桿菌感染%愛潑斯坦巴爾病毒感染
라간균,유문%포진병독4형,인%위종류%암%라간균감염%애발사탄파이병독감염
helicobacter pylori%herpesvirus 4,human%stomach neoplasms%carcinoma%helicobacter infections%ep-stein-barr virus infections
目的：探讨Epstein-Barr virus（EBV）、幽门螺旋杆菌（Hp）感染与胃癌发生的关系及二者的相互作用。方法采用聚合酶链反应（PCR）和原位杂交（ISH）技术检测100例胃癌组织（胃癌组）及82例胃炎组织（胃炎组）中EBV的感染情况，采用PCR技术检测Hp感染情况，分析EBV、Hp感染与胃癌患者临床病理特征的关系及二者的相关性。结果胃癌组EBV和Hp的感染阳性率均高于胃炎组（9.0%vs 0和56.0%vs 40.2%,均P＜0.05）。贲门胃体癌较胃窦癌EBV感染率高（16.3%vs 2.0%，P＜0.05），低分化癌较中高分化癌EBV、Hp感染率高（15.7%vs 2.0%和66.7%vs 44.9%,均P＜0.05），不同性别、年龄、民族及有无淋巴结转移间EBV、Hp感染率差异无统计学意义，不同发生部位间的Hp感染率差异无统计学意义。胃癌组EBV与Hp感染无相关性（r=0.137，P＞0.05）。结论 EBV、Hp感染是胃癌发生的2个独立因素，二者均与胃癌的恶性演进有关。
目的：探討Epstein-Barr virus（EBV）、幽門螺鏇桿菌（Hp）感染與胃癌髮生的關繫及二者的相互作用。方法採用聚閤酶鏈反應（PCR）和原位雜交（ISH）技術檢測100例胃癌組織（胃癌組）及82例胃炎組織（胃炎組）中EBV的感染情況，採用PCR技術檢測Hp感染情況，分析EBV、Hp感染與胃癌患者臨床病理特徵的關繫及二者的相關性。結果胃癌組EBV和Hp的感染暘性率均高于胃炎組（9.0%vs 0和56.0%vs 40.2%,均P＜0.05）。賁門胃體癌較胃竇癌EBV感染率高（16.3%vs 2.0%，P＜0.05），低分化癌較中高分化癌EBV、Hp感染率高（15.7%vs 2.0%和66.7%vs 44.9%,均P＜0.05），不同性彆、年齡、民族及有無淋巴結轉移間EBV、Hp感染率差異無統計學意義，不同髮生部位間的Hp感染率差異無統計學意義。胃癌組EBV與Hp感染無相關性（r=0.137，P＞0.05）。結論 EBV、Hp感染是胃癌髮生的2箇獨立因素，二者均與胃癌的噁性縯進有關。
목적：탐토Epstein-Barr virus（EBV）、유문라선간균（Hp）감염여위암발생적관계급이자적상호작용。방법채용취합매련반응（PCR）화원위잡교（ISH）기술검측100례위암조직（위암조）급82례위염조직（위염조）중EBV적감염정황，채용PCR기술검측Hp감염정황，분석EBV、Hp감염여위암환자림상병리특정적관계급이자적상관성。결과위암조EBV화Hp적감염양성솔균고우위염조（9.0%vs 0화56.0%vs 40.2%,균P＜0.05）。분문위체암교위두암EBV감염솔고（16.3%vs 2.0%，P＜0.05），저분화암교중고분화암EBV、Hp감염솔고（15.7%vs 2.0%화66.7%vs 44.9%,균P＜0.05），불동성별、년령、민족급유무림파결전이간EBV、Hp감염솔차이무통계학의의，불동발생부위간적Hp감염솔차이무통계학의의。위암조EBV여Hp감염무상관성（r=0.137，P＞0.05）。결론 EBV、Hp감염시위암발생적2개독립인소，이자균여위암적악성연진유관。
Objective To investigate the correlation between Epstein-Barrvirus (EBV) and H.pylori (Hp) infection and gastric cancer. Methods The EBV infection was examined by polymerase chain reaction (PCR) and in situ hybridiza-tion (ISH) in 100 samples of gastric cancer tissue and 82 samples of gastritis tissue. The Hp infection was detected by PCR. The correlation between EBV and Hp infection and clinical and pathological features was analyzed in patients with gastric cancer. Results The positive rates of EBV and Hp were significantly higher in gastric cancer tissues than those in gastritis tissues (9.0%vs 0 and 56.0%vs 40.2%, P<0.05). There was significantly higher infection rate in EBV in cardia gastric can-cer than that of gastric cancer (16.3%vs 2.0%,P<0.05). There were significantly higher infection rates in EBV and Hp in poorly differentiated carcinoma than those of well-differentiated carcinoma (15.7%vs 2.0%and 66.7%vs 44.9%, P<0.05). There were no significant differences in EBV and Hp infection between gender, age, nationality and lymph node metastasis (P>0.05). There was no significant difference in Hp infection between different parts of gastric cancer. There was no correla-tion between EBV and Hp infection in gastric cancer tissues (r=0.137, P>0.05). Conclusion EBV and Hp infection are two independent factors in the development of gastric cancer, and both of them are associated with the malignant evolution of gastric cancer.
