CAJ | 학술논문

目的：探讨介入取栓联合替罗非班在治疗急性下肢动脉栓塞的临床疗效及安全性。方法随机选取该院于2011年4月-2012年3月收治的急性下肢动脉栓塞患者52例(76肢)随机分为两组，对照组26例行Fogarty导管取栓术，治疗组26例患者除给予介入取栓外，术前术后给予替罗非班预防血栓形成，根据治愈率、死亡率、术后再栓率以及截肢率评价两组方法的疗效。结果两组患者均成功取除大部分栓子，无死亡病例；治疗组和对照组的治愈率、术后再栓率以及截肢率分别为92.1%(35/38)和78.9%(30/38)、7.9%(3/38)和21.0%(8/38)、2.6%(1/38)和13.2%(5/38)，差异有投机学性意义(P<0.01)。未发生出血等不良反应。结论Fogarty导管取栓术联合替罗非班对治疗急性下肢动脉栓塞的临床疗效及安全性均较好，且提升了手术成功率，具有较强的临床应用价值，值得临床推广。
목적：탐토개입취전연합체라비반재치료급성하지동맥전새적림상료효급안전성。방법수궤선취해원우2011년4월-2012년3월수치적급성하지동맥전새환자52례(76지)수궤분위량조，대조조26례행Fogarty도관취전술，치료조26례환자제급여개입취전외，술전술후급여체라비반예방혈전형성，근거치유솔、사망솔、술후재전솔이급절지솔평개량조방법적료효。결과량조환자균성공취제대부분전자，무사망병례；치료조화대조조적치유솔、술후재전솔이급절지솔분별위92.1%(35/38)화78.9%(30/38)、7.9%(3/38)화21.0%(8/38)、2.6%(1/38)화13.2%(5/38)，차이유투궤학성의의(P<0.01)。미발생출혈등불량반응。결론Fogarty도관취전술연합체라비반대치료급성하지동맥전새적림상료효급안전성균교호，차제승료수술성공솔，구유교강적림상응용개치，치득림상추엄。
Objective To investigate the clinical efficacy and safety of interventional thrombectomy combined with tirofiban in the treatment of acute lower extremity arterial embolism.Methods 52 cases of patients(76 limbs)with acute lower extremity arterial embolism admitted in our hospital from April, 2011 to March,2012 were randomly divided into treatment group (n=26)and control group(n=26).The control group was treated with Fogarty catheter embolectomy.Besides interventional thrombectomy, the treatment group was given tirofiban preoperatively and postoperatively for preventing the formation of thrombus. The clinical efficacy of the two groups was evaluated by cure rate, mortality,postoperative embolism relapse rate and amputation rate.Results Most thrombi in 62 cases were removed, and no death case.The cure rate, postoperative embolism relapse rate and amputation rate of the treatment group and the control group were 92.1%(35/38) and 78.9%(30/38), 7.9%(3/38) and 21.0%(8/38),2.6%(1/38)and 13.2%(5/38),respectively,and the differences between the two groups were statistically significant(P<0.01). And no bleeding and other adverse reactions occurred.Conclusion Fogarty catheter embolectomy combined with tirofiban is effective and safe in treating acute lower extremity arterial embolism, which can increase the success rate of the surgery with high clinical value, and is worthy to be recommended.