CAJ | 학술논문

刷状聚乙二醇（PEG）两亲性共聚物具有独特的性能和良好的应用前景，日益受到人们的重视。本文综述了刷状PEG两亲性共聚物的两种合成策略，即大分子单体法和主链-侧链偶联法，它们主要通过离子聚合、自由基聚合、开环聚合及各种耦合反应等实现。举例分析了这些方法的优缺点，并侧重于聚酯等生物可降解材料形成的刷状PEG共聚物。比较了直链PEG和刷状PEG共聚物胶束表面形态，简要分析了刷状PEG结构对纳米颗粒药物输送性能的影响，指出刷状PEG结构能延长体内循环时间从而提高药物疗效，但有效的合成方法及其胶束的体内外性能还需要更深入的探索。
쇄상취을이순（PEG）량친성공취물구유독특적성능화량호적응용전경，일익수도인문적중시。본문종술료쇄상PEG량친성공취물적량충합성책략，즉대분자단체법화주련-측련우련법，타문주요통과리자취합、자유기취합、개배취합급각충우합반응등실현。거례분석료저사방법적우결점，병측중우취지등생물가강해재료형성적쇄상PEG공취물。비교료직련PEG화쇄상PEG공취물효속표면형태，간요분석료쇄상PEG결구대납미과립약물수송성능적영향，지출쇄상PEG결구능연장체내순배시간종이제고약물료효，단유효적합성방법급기효속적체내외성능환수요경심입적탐색。
Brush copolymers with poly(ethylene glycol) (PEG) as side chains have received wide attentions due to their unique properties and potential applications. In this article,the synthesis strategies,including“grafting through”and“grafting onto”,their specific advantages and limitations are reviewed,with an emphasis on brush PEG copolymers based on biodegradable materials,such as polyesters. In each strategy,various polymerization techniques,such as ionic polymerization,radical polymerization,ring opening polymerization and their compatible partner various coupling reactions, are employed. Meanwhile,the surface morphologies of the micelles built from linear PEG copolymers and brush PEG copolymers are illustrated in this article,and the effects of the architecture of PEG brush on the formed nanoparticles’ properties in drug delivery are briefly discussed. Well-defined brush PEG structure can prolong circulation times,resulting in improvement in drug efficacy. However,the effective synthetic methods as well as the micelles’ in vivo and in vitro properties still need ongoing and further researches.