临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2014年
10期
831-833
,共3页
斑块状银屑病%卡泊三醇%卤米松%序贯治疗
斑塊狀銀屑病%卡泊三醇%滷米鬆%序貫治療
반괴상은설병%잡박삼순%서미송%서관치료
Plaque Psoriasis%Calcipotriol cream%Halometasone cream%Sequential therapy
目的：探讨卡泊三醇联合卤米松序贯治疗寻常型斑块状银屑病的疗效及安全性。方法选取96例寻常型斑块状银屑病患者，随机分为两组。治疗组联合使用卡泊三醇软膏和卤米松软膏，分三阶段进行序贯治疗；对照组单纯外用卡泊三醇软膏早、晚各1次。治疗后第2、4、6周对两组患者进行疗效判断和比较，并观察治疗过程出现的不良反应。结果联合治疗组在治疗后在第2、4、6周复诊时总有效率分别为54.17％、68.89％和84.44％；对照组在治疗后在第2、4、6周复诊时总有效率分别为33.33％、46.67％和63.41％。与对照组相比，治疗组在各个观察时间点疗效均优于对照组，差异均有统计学意义（ P <0.05）。不良反应主要表现为出现局部红斑、灼热、瘙痒和色素沉着，治疗结束后症状均能缓解。结论卡泊三醇联合卤米松序贯性治疗斑块状银屑病，效果显著，不良反应较轻，是较好的治疗方案。
目的：探討卡泊三醇聯閤滷米鬆序貫治療尋常型斑塊狀銀屑病的療效及安全性。方法選取96例尋常型斑塊狀銀屑病患者，隨機分為兩組。治療組聯閤使用卡泊三醇軟膏和滷米鬆軟膏，分三階段進行序貫治療；對照組單純外用卡泊三醇軟膏早、晚各1次。治療後第2、4、6週對兩組患者進行療效判斷和比較，併觀察治療過程齣現的不良反應。結果聯閤治療組在治療後在第2、4、6週複診時總有效率分彆為54.17％、68.89％和84.44％；對照組在治療後在第2、4、6週複診時總有效率分彆為33.33％、46.67％和63.41％。與對照組相比，治療組在各箇觀察時間點療效均優于對照組，差異均有統計學意義（ P <0.05）。不良反應主要錶現為齣現跼部紅斑、灼熱、瘙癢和色素沉著，治療結束後癥狀均能緩解。結論卡泊三醇聯閤滷米鬆序貫性治療斑塊狀銀屑病，效果顯著，不良反應較輕，是較好的治療方案。
목적：탐토잡박삼순연합서미송서관치료심상형반괴상은설병적료효급안전성。방법선취96례심상형반괴상은설병환자，수궤분위량조。치료조연합사용잡박삼순연고화서미송연고，분삼계단진행서관치료；대조조단순외용잡박삼순연고조、만각1차。치료후제2、4、6주대량조환자진행료효판단화비교，병관찰치료과정출현적불량반응。결과연합치료조재치료후재제2、4、6주복진시총유효솔분별위54.17％、68.89％화84.44％；대조조재치료후재제2、4、6주복진시총유효솔분별위33.33％、46.67％화63.41％。여대조조상비，치료조재각개관찰시간점료효균우우대조조，차이균유통계학의의（ P <0.05）。불량반응주요표현위출현국부홍반、작열、소양화색소침착，치료결속후증상균능완해。결론잡박삼순연합서미송서관성치료반괴상은설병，효과현저，불량반응교경，시교호적치료방안。
Objective To investigate the clinical efficacy and safety of calcipotriol cream combined with halometasone cream in the treat-ment of plaque psoriasis. Methods In this trail ,we randomly assigned 96 patients who had a plaque psoriasis to undergo a sequential therapy of calcipotriol cream combined with halometasone cream or calcipotriol cream only( control group). The whole patients were treated for 6 weeks. The patients were evaluated for efficacy on week 2,4 and 6 after the initial treatment. Adverse effects were also recorded at each vist. Results The total effective rate was 54. 17% after a sequential therapy for 2 weeks ,68. 89% for 4 weeks and 84. 44% for 6 weeks. In the control group,total effective rate at each time point was 33. 33%,46. 67% and 63. 41%. A significant difference was noticed between two groups( P <0. 05). A temporary local erythema,burning,itching and pigmentation may occurred during treatment,and all symptoms can relieve after the treatment. There was one serious adverse event in each group. Compared with control group,the sequential treatment group had lower incidence of adverse re-action( P <0. 05). Conclusion Curative effects of patients treated with a sequential therapy of calcipotriol cream combined with halometasone cream were better than the treatment of calcipotriol cream alone.
