CAJ | 학술논문

目的：检测超促排卵治疗过程中卵泡液内颗粒细胞卵泡刺激素受体（ FSHR ）的表达水平，探讨FSHR表达与体外受精-胚胎移植（ IVF-ET）中卵子质量和临床妊娠率的关系。方法随机选择在本中心行第一周期IVF-ET的患者35例。采卵日收集卵泡液中的颗粒细胞，检测FSHR的表达。结果卵子的卵裂率随颗粒细胞FSHR表达强度的增加而升高（r＝0．681，P＜0．05）；卵子的受精率随颗粒细胞中FSHR表达的增加而升高（r＝0．647，P＜0．05）；与临床妊娠组相比，非妊娠组患者卵泡液中颗粒细胞FSHR表达水平显著降低，差异有统计学意义（P＜0．05），年龄、不孕年限、获卵率、卵子成熟度、优胚率差异无统计学意义。结论在IVF-ET中，卵泡液中颗粒细胞FSHR的表达水平将会影响卵子的质量，进而影响临床妊娠率。
목적：검측초촉배란치료과정중란포액내과립세포란포자격소수체（ FSHR ）적표체수평，탐토FSHR표체여체외수정-배태이식（ IVF-ET）중란자질량화림상임신솔적관계。방법수궤선택재본중심행제일주기IVF-ET적환자35례。채란일수집란포액중적과립세포，검측FSHR적표체。결과란자적란렬솔수과립세포FSHR표체강도적증가이승고（r＝0．681，P＜0．05）；란자적수정솔수과립세포중FSHR표체적증가이승고（r＝0．647，P＜0．05）；여림상임신조상비，비임신조환자란포액중과립세포FSHR표체수평현저강저，차이유통계학의의（P＜0．05），년령、불잉년한、획란솔、란자성숙도、우배솔차이무통계학의의。결론재IVF-ET중，란포액중과립세포FSHR적표체수평장회영향란자적질량，진이영향림상임신솔。
Objective To determine the expression of follicle stimulating hormone receptor (FSH-R),and to study the relation-ship between FSHR expression with in vitro fertilization and embryo transfer ( IVF-ET) .Methods Thirty-five subjects receiving the first cycle of IVF-ET were enrolled from our center .The follicular fluid was collected ,and FSHR was measured in the day for ova collection .Results The fertilization rate with increasing content of FSHR increased (r=0.647,P<0.05);Compared with the pregnant group ,the non-pregnant group FSHR expression levels in patients with follicular granulosa cells was significantly lower ,and the difference was statistically significant (P<0.05).Conclusion The expression levels of FSHR affect ovas quality ,thereby affecting the pregnancy rate .