潍坊医学院学报
濰坊醫學院學報
유방의학원학보
JOURNAL OF WEIFANG MEDICAL COLLEGE
2014年
3期
226-228
,共3页
子痫前期%可溶性人类白细胞抗原G%妊娠
子癇前期%可溶性人類白細胞抗原G%妊娠
자간전기%가용성인류백세포항원G%임신
Preeclampsia%Soluble human leukocyte antigen G%Pregnancy
目的：通过检测子痫前期（ PE）孕妇血清中可溶性人类白细胞抗原G（ sHLA-G）水平的变化，探讨其与PE的关系。方法采用ELISA法检测轻度、重度PE及健康孕妇血清中的可溶性HLA-G（ sHLA-G）水平。结果各组孕妇外周血sHLA-G水平：轻、重度PE组孕妇分别为（44．32±10．72） U/ml，（30．08±9．12） U/ml，对照组为（90．52±11．32）U/ml，与对照组比较，差异有统计学意义（P＜0．01）；重度PE组与轻度PE组比较，差异亦有统计学意义（P＜0．01）。结论与健康孕妇相比，sHLA-G在PE孕妇外周血中呈明显低表达，sHLA-G表达水平的异常可能与PE的发病有关。
目的：通過檢測子癇前期（ PE）孕婦血清中可溶性人類白細胞抗原G（ sHLA-G）水平的變化，探討其與PE的關繫。方法採用ELISA法檢測輕度、重度PE及健康孕婦血清中的可溶性HLA-G（ sHLA-G）水平。結果各組孕婦外週血sHLA-G水平：輕、重度PE組孕婦分彆為（44．32±10．72） U/ml，（30．08±9．12） U/ml，對照組為（90．52±11．32）U/ml，與對照組比較，差異有統計學意義（P＜0．01）；重度PE組與輕度PE組比較，差異亦有統計學意義（P＜0．01）。結論與健康孕婦相比，sHLA-G在PE孕婦外週血中呈明顯低錶達，sHLA-G錶達水平的異常可能與PE的髮病有關。
목적：통과검측자간전기（ PE）잉부혈청중가용성인류백세포항원G（ sHLA-G）수평적변화，탐토기여PE적관계。방법채용ELISA법검측경도、중도PE급건강잉부혈청중적가용성HLA-G（ sHLA-G）수평。결과각조잉부외주혈sHLA-G수평：경、중도PE조잉부분별위（44．32±10．72） U/ml，（30．08±9．12） U/ml，대조조위（90．52±11．32）U/ml，여대조조비교，차이유통계학의의（P＜0．01）；중도PE조여경도PE조비교，차이역유통계학의의（P＜0．01）。결론여건강잉부상비，sHLA-G재PE잉부외주혈중정명현저표체，sHLA-G표체수평적이상가능여PE적발병유관。
Objective To discuss the connection between soluble human leukocyte antigen G and preclampsia by detecting the maternal soluble human leukocyte antigen G (sHLA-G) level.Methods The soluble HLA-G(sHLA-G) levels of the mild preeclampsia groups,severe preeclampsia groups and normal pregnancies groups were examined by ELISA .Results The sHLA-G levels in peripheral blood in mild and severe preeclampsia group were (44.32 ±10.72)U/ml,(30.08 ±9.12)U/ml respectively.All were significantly lower than that in the control group(P<0.01),which was (90.52 ±11.32)U/ml.There was also statistical difference between mild and severe preeclampsia group(P<0.01).Conclusion The level of sHLA-G in the peripheral blood in women with preeclampsia is significantly lower than that in normal pregnant women .The abnormal level of sHLA-G might be associated with the pathogenesis of preeclampsia .
