CAJ | 학술논문

目的：探讨丹参酮ⅡA联合神经节苷脂治疗外伤性脑梗死的临床疗效。方法将126例外伤性脑梗死患者按照入院先后分为观察组和对照组各63例。对照组采用神经节苷脂治疗，观察组采用丹参酮ⅡA联合神经节苷脂治疗。治疗14 d后，比较2组的疗效和日常生活能力评分状况，评价联合用药的临床价值。结果观察组痊愈、显效、有效和无效分别有15、35、9和4例，总有效率为93.65％，对照组为80.95％，观察组总有效率显著高于对照组（ P＜0.05）。2组日常生活能力较治疗前均明显提升（P＜0.05）。观察组治疗后Barthel指数评分75.2±14.6，对照组为51.7±13.8，观察组明显优于对照组（P＜0.05）。2组在不良反应发生方面比较差异无统计学意义（P＞0.05）。结论丹参酮ⅡA联合神经节苷脂治疗外伤性脑梗死可有效提升治疗效果，改善患者日常生活能力，未增加不良反应。
목적：탐토단삼동ⅡA연합신경절감지치료외상성뇌경사적림상료효。방법장126예외상성뇌경사환자안조입원선후분위관찰조화대조조각63례。대조조채용신경절감지치료，관찰조채용단삼동ⅡA연합신경절감지치료。치료14 d후，비교2조적료효화일상생활능력평분상황，평개연합용약적림상개치。결과관찰조전유、현효、유효화무효분별유15、35、9화4례，총유효솔위93.65％，대조조위80.95％，관찰조총유효솔현저고우대조조（ P＜0.05）。2조일상생활능력교치료전균명현제승（P＜0.05）。관찰조치료후Barthel지수평분75.2±14.6，대조조위51.7±13.8，관찰조명현우우대조조（P＜0.05）。2조재불량반응발생방면비교차이무통계학의의（P＞0.05）。결론단삼동ⅡA연합신경절감지치료외상성뇌경사가유효제승치료효과，개선환자일상생활능력，미증가불량반응。
Objective To investigate the clinical therapeutic value of Tanshinone Ⅱ A combined ganglioside in the treat-ment of traumatic cerebral infarction. Methods One hundred and twenty-six traumatic cerebral infarction patients were select-ed and were divided into control group and observation group according to the time of admission. The control group received ganglioside treatment ,while observation group acceptd Tanshinone Ⅱ A combined ganglioside treatment.At the 14 d after treatment ,the efficacy and activities of daily living score position were compared to evaluate the clinical value of combination therapy. Results The cure ,effective ,effective and ineffective number of cases were 15 ,35 ,9 and 4 cases ,respectively ,and the total effective rate reached 93.65% ,which was significantly higher than that in control group (P<0.05). Compared with that before treatment ,the daily living activities of both 2 groups improved significantly (P<0.05). After the treatment ,the Barthel index score of observation group and control group were 75.2 ± 14.6 and 51.7 ± 13.8 ,respectively ,there was signifi-cant difference between the two groups (P<0.05). For the incidence of adverse reactions ,two groups showed no significant difference (P>0.05). Conclusion Tanshinone ⅡA combined ganglioside for treatment of traumatic cerebral infarction can en-hance the therapeutic effect ,improve the ability of daily lives without increasing adverse reactions.