CAJ | 학술논문

目的：了解无症状神经梅毒的临床及实验室特征，以减少临床中的误诊误治。方法对2008年8月~2011年8月收治的27例无症状神经梅毒从年龄、性别、实验室、治疗、转归方面进行回顾性分析。结果27例无症状神经梅毒患者，血清RPR滴度从1︰8到1︰128不等。合并HIV感染的6例患者中，CD4细胞计数小于350个/μL者4例。在脑脊液检测中22例出现白细胞升高（81.5%），6例出现脑脊液蛋白升高（22.2%），9例出现颅压升高（33.3%）。结论在临床工作中，及时发现无症状神经梅毒，特别是HIV感染人群，及时治疗可以有效减少性症状性神经梅毒的发生。
목적：료해무증상신경매독적림상급실험실특정，이감소림상중적오진오치。방법대2008년8월~2011년8월수치적27례무증상신경매독종년령、성별、실험실、치료、전귀방면진행회고성분석。결과27례무증상신경매독환자，혈청RPR적도종1︰8도1︰128불등。합병HIV감염적6례환자중，CD4세포계수소우350개/μL자4례。재뇌척액검측중22례출현백세포승고（81.5%），6례출현뇌척액단백승고（22.2%），9례출현로압승고（33.3%）。결론재림상공작중，급시발현무증상신경매독，특별시HIV감염인군，급시치료가이유효감소성증상성신경매독적발생。
Objective To understand the clinical and laboratory features of asymptomatic neurosyphilis in order to reduce the clinical misdiagnosis and mistreatment. Methods The age, sex, laboratory, treatment and prognosis of 27 cases with asymptomatic neurosyphilis selected from August 2008 to August 2011 were retrospectively analyzed. Results In 27 cases with asymptomatic neurosyphilis, serum RPR titers ranged from 1 ︰ 8 to 1 ︰ 128. In 6 cases complicated with HIV infection, the CD4 cell counts of 4 cases was less than 350 cells / μL. In the detection of cerebrospinal fluid, 22 cases(81.5%) were complicated with leukocytosis, 6 cases(22.2%) were complicated with elevated cerebrospinal fluid protein concentration, and 9 cases(33.3%) were complicated with increased intracranial pressure. Conclusion In clinical work, discover and therapy asymptomatic neurosyphilis in time, especially in HIV infected patients, can effectively reduce the incidence of symptomatic neurosyphilis.