CAJ | 학술논문

目的：观察比亚芬预防乳腺癌改良根治术后胸壁放射性皮肤损伤的效果。方法57例乳腺癌改良根治术后患者随机分两组，治疗组29例在第1次放疗后给予比亚芬涂抹照射野皮肤，对照组28例做常规放疗皮肤护理。结果治疗组和对照组Ⅰ、Ⅱ、Ⅲ级放射性皮肤损伤的发生率分别为55.2%、34.5%、10.3%和17.9%、42.9%、39.3%；累积剂量25Gy时急性放射性皮肤损伤的发生率分别为75.0%和48.3%。两组差异有统计学意义（P＜0.05）。结论早期使用比亚芬能有效降低乳腺癌改良根治术后胸壁放射性皮肤损的程度，延缓损伤发生的时间。
목적：관찰비아분예방유선암개량근치술후흉벽방사성피부손상적효과。방법57례유선암개량근치술후환자수궤분량조，치료조29례재제1차방료후급여비아분도말조사야피부，대조조28례주상규방료피부호리。결과치료조화대조조Ⅰ、Ⅱ、Ⅲ급방사성피부손상적발생솔분별위55.2%、34.5%、10.3%화17.9%、42.9%、39.3%；루적제량25Gy시급성방사성피부손상적발생솔분별위75.0%화48.3%。량조차이유통계학의의（P＜0.05）。결론조기사용비아분능유효강저유선암개량근치술후흉벽방사성피부손적정도，연완손상발생적시간。
Objective To observe the effect of biafine cream to prevent acute radioactive dermatitis in patients with breast cancer after modified mastectomy. Methods 59 patients with breast cancer after modified mastectomy were randomized into two groups. Biafine cream was used in 29 cases in treatment group since the first radiotherapy,while another 28 cases in control group were given conventional radiotherapy nursing method. Results The rates of acute radioactive dermatitis of gradeⅠ,Ⅱ,Ⅲin the treatment group and in the control group were 55.2%,34.5%,10.3%and 17.9%,42.9%,39.3%, respectively; in the cumulative dose of 25Gy,the incidence rate of acuter radioactive dermatitis were75.0%and 48.3%, respectively.There was a significant difference between them(P<0.05). Conclusion Biafine cream can prevent acute radiation response in skin in breast cancer patients after modified mastectomy, and can postpone the occurrence of acute radiation dermatitis.