中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2013年
20期
27-28,32
,共3页
基因多态性%胃癌%遗传易感性
基因多態性%胃癌%遺傳易感性
기인다태성%위암%유전역감성
Polymorphism%Gastric cancer%Genetic susceptibility
目的：探讨人类8-羟基鸟嘌呤DNA糖苷酶1（hOGG 1）基因多态性与胃癌遗传易感性的关系。方法收集河南郑州和开封地区98例胃癌患者和80例非肿瘤对照组志愿者外周血样，应用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）检测法检测胃癌人群的外周血中DNA损伤修复酶基因多态性，分析其与肿瘤遗传易感性的关系。结果 hOGG1Ser326Cys基因的各基因型频率在胃癌组和对照组间的分布差异有统计学意义（P＜0.05）。携带Cys326Cys基因型者胃癌的发病风险增加1.7倍（OR=1.706，95%CI=0.341～2.462，P=0.002）。hOGG1Ser 326Cys基因多态性与酒的交互作用增加胃癌的发病风险（S＞1，API=0.38）。结论Cys326Cys基因型是胃癌发病的危险基因型，携带Cys易感基因与饮酒交互作用时可能增加患胃癌的易感性。
目的：探討人類8-羥基鳥嘌呤DNA糖苷酶1（hOGG 1）基因多態性與胃癌遺傳易感性的關繫。方法收集河南鄭州和開封地區98例胃癌患者和80例非腫瘤對照組誌願者外週血樣，應用聚閤酶鏈反應-限製性片段長度多態性（PCR-RFLP）檢測法檢測胃癌人群的外週血中DNA損傷脩複酶基因多態性，分析其與腫瘤遺傳易感性的關繫。結果 hOGG1Ser326Cys基因的各基因型頻率在胃癌組和對照組間的分佈差異有統計學意義（P＜0.05）。攜帶Cys326Cys基因型者胃癌的髮病風險增加1.7倍（OR=1.706，95%CI=0.341～2.462，P=0.002）。hOGG1Ser 326Cys基因多態性與酒的交互作用增加胃癌的髮病風險（S＞1，API=0.38）。結論Cys326Cys基因型是胃癌髮病的危險基因型，攜帶Cys易感基因與飲酒交互作用時可能增加患胃癌的易感性。
목적：탐토인류8-간기조표령DNA당감매1（hOGG 1）기인다태성여위암유전역감성적관계。방법수집하남정주화개봉지구98례위암환자화80례비종류대조조지원자외주혈양，응용취합매련반응-한제성편단장도다태성（PCR-RFLP）검측법검측위암인군적외주혈중DNA손상수복매기인다태성，분석기여종류유전역감성적관계。결과 hOGG1Ser326Cys기인적각기인형빈솔재위암조화대조조간적분포차이유통계학의의（P＜0.05）。휴대Cys326Cys기인형자위암적발병풍험증가1.7배（OR=1.706，95%CI=0.341～2.462，P=0.002）。hOGG1Ser 326Cys기인다태성여주적교호작용증가위암적발병풍험（S＞1，API=0.38）。결론Cys326Cys기인형시위암발병적위험기인형，휴대Cys역감기인여음주교호작용시가능증가환위암적역감성。
Objective To investigate the relationship between polymorphism in human 8-oxoguanine DNA glycosylase 1(hOGG1) and xeroderma pigmentosum group D (XPD) and genetic susceptibility to gastric cancer. Methods The peripheral blood samples of 98 cases of gastric cancer and 80 non-tumor volunteers(control group) in Zhengzhou and Kaifeng of Henan were collected, the peripheral DNA repair enzyme gene polymorphism in gastric cancer populations were detected by using polymerase chain reaction restriction fragment length polymorphism(PCR-RFLP), and it's relationship with genetic susceptibility to cancer was analyzed. Results There were significant differences in genotypes frequency of hOGG1Ser326Cys and XPD Lys751Gln between gastric cancer group and control group (P < 0.05). Lys751Gln genotype had the 1.7 times inceased risk of developing gastric cancer (OR=1.706, 95%CI=0.341 ~ 2.462,P=0.002). The interactions between hOGG1Ser 326Cys polymorphism and alcohol and between XPDLys751Gln polymorphism and alcohol increased the onset risk of gastric cancer(S>1, API=0.38). Conclusion The Lys751Gln genotype and susceptibility to gastric cancer in individuals can be relevant. The interaction between carrying Cys or Gln gene-gene and alcohol can increase the susceptibility to gastric cancer.
