中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
6期
1158-1161
,共4页
血液肿瘤%嵌合抗原受体%免疫疗法%T淋巴细胞
血液腫瘤%嵌閤抗原受體%免疫療法%T淋巴細胞
혈액종류%감합항원수체%면역요법%T림파세포
Hematologic neoplasms%Chimeric antigen receptor%Immunotherapy%T-lymphocytes
嵌合抗原受体(CAR)为基础的免疫治疗,发展经历了近25年,它已经从一个新兴的复杂的技术转变成为恶性肿瘤治疗的一种新策略。随着重组 DNA 技术的不断发展以及对信号传导通路的不断研究深入,CAR 技术也在不断革新并开始为临床服务。而CAR疗法以其在血液肿瘤的中独特优势在治疗中不断取得突破,见证了CAR技术成熟的过程。本文主要回顾在血液肿瘤研究中CAR技术的革新、应用现状和前景。
嵌閤抗原受體(CAR)為基礎的免疫治療,髮展經歷瞭近25年,它已經從一箇新興的複雜的技術轉變成為噁性腫瘤治療的一種新策略。隨著重組 DNA 技術的不斷髮展以及對信號傳導通路的不斷研究深入,CAR 技術也在不斷革新併開始為臨床服務。而CAR療法以其在血液腫瘤的中獨特優勢在治療中不斷取得突破,見證瞭CAR技術成熟的過程。本文主要迴顧在血液腫瘤研究中CAR技術的革新、應用現狀和前景。
감합항원수체(CAR)위기출적면역치료,발전경력료근25년,타이경종일개신흥적복잡적기술전변성위악성종류치료적일충신책략。수착중조 DNA 기술적불단발전이급대신호전도통로적불단연구심입,CAR 기술야재불단혁신병개시위림상복무。이CAR요법이기재혈액종류적중독특우세재치료중불단취득돌파,견증료CAR기술성숙적과정。본문주요회고재혈액종류연구중CAR기술적혁신、응용현상화전경。
Chimeric antigen receptor-(CAR-) based immunotherapy has been under development for almost 25 years, over which period it has progressed from a new but cumbersome technology to an emerging therapeutic modality for malignant disease. With the development of recombinant DNA technology, as well as signaling pathways continue to study in depth, CAR technology has begun to innovated and be used for clinical services. The CAR therapy in hematological malignancies of its unique advantages in the treatment of hematologic malignancies continue to make breakthroughs, witnessed the CAR technology maturation process. In this paper, we reviewed the technology innovation, application status and prospects of CAR technology in hematological malignancies.