CAJ | 학술논문

目的：观察介入与单纯药物治疗对颅内前循环重度动脉粥样硬化狭窄的远期预后。方法92例患者随机分组治疗，观察组行介入治疗，对照组给予单纯药物治疗。记录2组患者的终点事件，并记录NIHSS量表评分。比较2组终点事件累积发生率及疾病严重程度。结果2组终点事件累积发生率无显著差异，但观察组30 d后缺血性卒中复发率（8.3％）比对照组的（22.7％）明显减少，且观察组围手术期并发症发生率8.3％。脑卒中近期（1～6个月）预后病情明显好转（ P＜0.05）。结论血管内介入治疗的30d后缺血性卒中复发率明显减少，且脑卒中近期预后好，但围手术期并发症发生率高，可能导致介入治疗与药物治疗的远期疗效无显著差异。
목적：관찰개입여단순약물치료대로내전순배중도동맥죽양경화협착적원기예후。방법92례환자수궤분조치료，관찰조행개입치료，대조조급여단순약물치료。기록2조환자적종점사건，병기록NIHSS량표평분。비교2조종점사건루적발생솔급질병엄중정도。결과2조종점사건루적발생솔무현저차이，단관찰조30 d후결혈성졸중복발솔（8.3％）비대조조적（22.7％）명현감소，차관찰조위수술기병발증발생솔8.3％。뇌졸중근기（1～6개월）예후병정명현호전（ P＜0.05）。결론혈관내개입치료적30d후결혈성졸중복발솔명현감소，차뇌졸중근기예후호，단위수술기병발증발생솔고，가능도치개입치료여약물치료적원기료효무현저차이。
Objective To investigate the long-term outcome of patients with severe intracranial atherosclerotic stenosis of anterior circulation after endovascular treatment and drug treatment.Methods Ninety -two cases were selected as observation group (48 cases) who accepted endovascular treatment ,and control group were afforded only medicine treatment.The outcome events were recorded ,and the NIHSS scores were evaluated.The outcome events and severity of both groups were compared.Results The outcome events between groups had no significant differences ,however ,the recurrence rate of ischemic stroke af-ter 30d in observation group (8.3% ) was significant lower than that of control group (22.7% ). The incidence of complication in perioperative period in observation group was 8.3%. The short-term prognosis (1-6-month) of stroke improved markedly (P<0.05). Conclusion The recurrence rate of ischemic stroke after 30d in observation group reduces significantly ,besides the short-term prognosis of stroke is a good outcome.However ,there is a high incidence of complication in the perioperative peri-od ,probably resulting in no difference in long-term outcome between observation and control group.