CAJ | 학술논문

近年来研究已认识到血脂异常的实质是脂蛋白和载脂蛋白(apolipoprotein,Apo)的异常, Apo 作为脂蛋白中的蛋白质部分,在结合和转运脂质及稳定脂蛋白的结构上、调节脂蛋白代谢关键酶活性以及脂蛋白受体的识别等方面发挥极为重要的作用.Apo 参与了人体脂类代谢的全过程,是目前揭示心脑血管疾病机制最受关注的课题.载脂蛋白 A5(apolipoproteinA5,ApoA5)基因自2001年被发现以来,一度成为近年来研究的热点.现将 ApoA5的结构功能、作用以及 ApoA5基因单核苷酸多态性与冠心病的关系进行综述.
근년래연구이인식도혈지이상적실질시지단백화재지단백(apolipoprotein,Apo)적이상, Apo 작위지단백중적단백질부분,재결합화전운지질급은정지단백적결구상、조절지단백대사관건매활성이급지단백수체적식별등방면발휘겁위중요적작용.Apo 삼여료인체지류대사적전과정,시목전게시심뇌혈관질병궤제최수관주적과제.재지단백 A5(apolipoproteinA5,ApoA5)기인자2001년피발현이래,일도성위근년래연구적열점.현장 ApoA5적결구공능、작용이급 ApoA5기인단핵감산다태성여관심병적관계진행종술.
Research have realized that essence of dyslipidemia is lipoprotein and apolipoprotein, apolipoprotein as a part of protein of lipoprotein, play an important role in binding,conveying and stabilizing the construction of lipoprotein, regulating key enzyme activity of proteometabolism, and identifying lipoprotein receptor. Apolipoprotein has been participating whole process of human lipid metabolism, is hot topic in revealing mechanism of cardio and cerebral vessels diseases.ApolipoproteinA5 gene founded since 2001,has been topic at one time. Now we reviewed construction and effect of apolipoproteinA5, association of apolipoproteinA5 nucleotide polymorphism and coronary artery disease.