CAJ | 학술논문

目的：比较 HER2蛋白在胃腺癌组织的表达与患者的年龄、性别、部位、分化、新的WHO分类以及TNM 分期等临床病理学参数的相关性。方法：使用免疫组织化学（IHC）方法检测胃腺癌患者中 HER2蛋白的表达，以修订后HercepTest评分标准进行评分。χ2检验分析HER2蛋白在胃腺癌组织中的表达与临床病理学参数的相关性。结果：590例患者中位年龄58．6岁，男女比例1．91∶1，其中Ⅲ＋Ⅳ期胃腺癌患者461例。使用修订后 HercepTest评分标本准进行判读为HER2（3＋）阳性表达患者共51例（51/590），其中Ⅲ＋Ⅳ期胃腺癌中的HER2（3＋）阳性表达患者45例。 HER2蛋白阳性过表达与肿瘤最大长径、分化、新的WHO分型、TNM 分期相关，而与患者的年龄、性别、肿瘤部位、浸润深度无相关。结论：HER2蛋白在胃腺癌组织中的表达与胃腺癌的肿瘤分化、新的WHO分型、TNM 分期相关，有可能作为判断胃癌生物学行为的指标及为靶向治疗提供依据。
목적：비교 HER2단백재위선암조직적표체여환자적년령、성별、부위、분화、신적WHO분류이급TNM 분기등림상병이학삼수적상관성。방법：사용면역조직화학（IHC）방법검측위선암환자중 HER2단백적표체，이수정후HercepTest평분표준진행평분。χ2검험분석HER2단백재위선암조직중적표체여림상병이학삼수적상관성。결과：590례환자중위년령58．6세，남녀비례1．91∶1，기중Ⅲ＋Ⅳ기위선암환자461례。사용수정후 HercepTest평분표본준진행판독위HER2（3＋）양성표체환자공51례（51/590），기중Ⅲ＋Ⅳ기위선암중적HER2（3＋）양성표체환자45례。 HER2단백양성과표체여종류최대장경、분화、신적WHO분형、TNM 분기상관，이여환자적년령、성별、종류부위、침윤심도무상관。결론：HER2단백재위선암조직중적표체여위선암적종류분화、신적WHO분형、TNM 분기상관，유가능작위판단위암생물학행위적지표급위파향치료제공의거。
Objective :To investigate the expression of HER2 protein and their association with clinicopathology fea-tures in gastric adenocarcinoma .Methods :The HER2 status was evaluated using immunohistochemistry .The modified Hercep Test scoring criterion was used to assess HER2 protein expression .The association between HER2 expression and clinicopathological features was analyzed by χ2 test .Results:The median age of patients was 58 .6 years ,and the male to female ratio was 1 .91∶1 ,Positive expression of HER2 protein (3+ ) was found in 51(51/590)cases of gastric adenocarcinoma by the modified HercepTest scoring criterion ,and in 45(45/590) gastric adenocarcinoma of the Ⅲ andⅣ stage ,There was significantly positive association between HER2 over-expression and tumor differentiation and di-ameter ,New WHO classification ,the TMN stage .NO significang association was observed between HER2 protein ex-pression and patients’age ,gender ,tumor location and invasion depth .Conclusion:There was significantly positive asso-ciation between HER2 expression status and tumor differentiation ,new WHO classification ,the TMN stage in gastric adenocarcinoma ,it maybe of helpful to judge the biological behavior ,guide the treatment for patients .