国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
22期
3435-3438
,共4页
原发性高血压%依那普利%比索洛尔%疗效%安全性
原髮性高血壓%依那普利%比索洛爾%療效%安全性
원발성고혈압%의나보리%비색락이%료효%안전성
Essential hypertension%Enalapril%Bisoprolol%Efficacy%Safety
目的 探讨比索洛尔(Bisoprolol Fumarate)联合依那普利(Enalapril maleate tablets)治疗原发性高血压(essential hypertension)的临床疗效以及用药安全性.方法 收集2011年5月至2013年5月本院收治的96例原发性高血压患者,随机分为对照组和观察组各48例.对照组予依那 普利5 ～ 10mg,每日2次口服；观察组在对照组服药方案基础上加用比索洛尔2.5～5 mg,每日1次口服,以4周为1个疗程.监测患者治疗前后的血压、心率、尿常规、血常规、肝功能、肾功能,并且记录患者服药期间产生的不良反应.结果 观察组总有效率为93.75％,对照组总有效率为81.25％,观察组总有效率高于对照组,差异有统计学意义(x 2=3.4,P＜0.05).两组患者在本研究过程中未出现心脑事件,也未发现低血压,心率、血常规、尿常规、肝肾功能均在正常范围.结论 依那普利联合比索洛尔治疗原发性高血压具有理想的临床疗效,不良反应少.
目的 探討比索洛爾(Bisoprolol Fumarate)聯閤依那普利(Enalapril maleate tablets)治療原髮性高血壓(essential hypertension)的臨床療效以及用藥安全性.方法 收集2011年5月至2013年5月本院收治的96例原髮性高血壓患者,隨機分為對照組和觀察組各48例.對照組予依那 普利5 ～ 10mg,每日2次口服；觀察組在對照組服藥方案基礎上加用比索洛爾2.5～5 mg,每日1次口服,以4週為1箇療程.鑑測患者治療前後的血壓、心率、尿常規、血常規、肝功能、腎功能,併且記錄患者服藥期間產生的不良反應.結果 觀察組總有效率為93.75％,對照組總有效率為81.25％,觀察組總有效率高于對照組,差異有統計學意義(x 2=3.4,P＜0.05).兩組患者在本研究過程中未齣現心腦事件,也未髮現低血壓,心率、血常規、尿常規、肝腎功能均在正常範圍.結論 依那普利聯閤比索洛爾治療原髮性高血壓具有理想的臨床療效,不良反應少.
목적 탐토비색락이(Bisoprolol Fumarate)연합의나보리(Enalapril maleate tablets)치료원발성고혈압(essential hypertension)적림상료효이급용약안전성.방법 수집2011년5월지2013년5월본원수치적96례원발성고혈압환자,수궤분위대조조화관찰조각48례.대조조여의나 보리5 ～ 10mg,매일2차구복；관찰조재대조조복약방안기출상가용비색락이2.5～5 mg,매일1차구복,이4주위1개료정.감측환자치료전후적혈압、심솔、뇨상규、혈상규、간공능、신공능,병차기록환자복약기간산생적불량반응.결과 관찰조총유효솔위93.75％,대조조총유효솔위81.25％,관찰조총유효솔고우대조조,차이유통계학의의(x 2=3.4,P＜0.05).량조환자재본연구과정중미출현심뇌사건,야미발현저혈압,심솔、혈상규、뇨상규、간신공능균재정상범위.결론 의나보리연합비색락이치료원발성고혈압구유이상적림상료효,불량반응소.
Objective To investigate the clinical efficacy and drug safety of Bisoprolol fumarate combined with Enalapril maleate tablets in essential hypertension.Methods From May 2011 to May 2013,we collected 96 patients with primary hypertension,by random drawing method,they were divided into the control group and the treatment group with 48 cases in each group.The control group was treated with Enalapril 5-10 mg,orally twice a day,the observation group was treated with Bisoprolol medication scheme for 2.5-5 mg,oral once daily,4 weeks as a course of treatment,blood pressure of patients before and after treatment,as well as the heart rate monitor,urine routine,blood routine,liver function,renal function,and adverse reactions were recorded during the medication.Results In the observation group,the total efficiency was 93.75％,the total effective rate of control group was 81.25％,total effective rate of observation group was higher than that of the control group,with significant difference between the two groups (x 2=3.4,P ＜ 0.05).No cardiovascular events occurred in the process of the research,no blood pressure found,heart rate,blood routine,urine routine,liver and kidney function were within the normal range.Conclusion The clinicat curative effect of Enalapril combined with Bisoprolol in the treatment of essential hypertension is ideal,with less adverse reaction.
