中华老年多器官疾病杂志
中華老年多器官疾病雜誌
중화노년다기관질병잡지
CHINESE JOURNAL OF MULTIPLE ORGAN DISEASES IN THE ELDERLY
2014年
5期
12-16
,共5页
糖尿病,2型%轻度认知功能障碍%胱抑素C基因%危险因素
糖尿病,2型%輕度認知功能障礙%胱抑素C基因%危險因素
당뇨병,2형%경도인지공능장애%광억소C기인%위험인소
diabetes mellitus,type 2%mild cognitive impairment%cystatin C gene%risk factors
目的：研究老年2型糖尿病（T2DM）患者的胱抑素C基因（CST3）多态性与其发生轻度认知功能障碍（MCI）的关系，探讨发生MCI的相关危险因素。方法选取156例老年T2DM患者，分为MCI组和认知功能正常组（NC），均使用简易智力状态量表、蒙特利尔认知评估量表、焦虑自评量表、流行病学调查用抑郁自评量表、帕金森病筛查量表、日常生活能力量表、全面衰退量表等进行测验，聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）CST3基因多态性。结果 A等位基因频率在MCI组与NC组分别为80.4%和90.9%，B等位基因频率在MCI组与NC组分别为19.6%和9.1%，两组比较c2＝7.005，P＝0.008，差异均有统计学意义。在0.05检验水准下，携带B等位基因（OR：2.279，95% CI：1.064～4.882，P＝0.034）与T2DM发生MCI危险性的关联差异有统计学意义。结论携带B等位基因是老年T2DM患者发生MCI的危险因素。检测CST3多态性有利于老年T2DM患者认知障碍的早期诊断。
目的：研究老年2型糖尿病（T2DM）患者的胱抑素C基因（CST3）多態性與其髮生輕度認知功能障礙（MCI）的關繫，探討髮生MCI的相關危險因素。方法選取156例老年T2DM患者，分為MCI組和認知功能正常組（NC），均使用簡易智力狀態量錶、矇特利爾認知評估量錶、焦慮自評量錶、流行病學調查用抑鬱自評量錶、帕金森病篩查量錶、日常生活能力量錶、全麵衰退量錶等進行測驗，聚閤酶鏈反應-限製性片段長度多態性分析（PCR-RFLP）CST3基因多態性。結果 A等位基因頻率在MCI組與NC組分彆為80.4%和90.9%，B等位基因頻率在MCI組與NC組分彆為19.6%和9.1%，兩組比較c2＝7.005，P＝0.008，差異均有統計學意義。在0.05檢驗水準下，攜帶B等位基因（OR：2.279，95% CI：1.064～4.882，P＝0.034）與T2DM髮生MCI危險性的關聯差異有統計學意義。結論攜帶B等位基因是老年T2DM患者髮生MCI的危險因素。檢測CST3多態性有利于老年T2DM患者認知障礙的早期診斷。
목적：연구노년2형당뇨병（T2DM）환자적광억소C기인（CST3）다태성여기발생경도인지공능장애（MCI）적관계，탐토발생MCI적상관위험인소。방법선취156례노년T2DM환자，분위MCI조화인지공능정상조（NC），균사용간역지력상태량표、몽특리이인지평고량표、초필자평량표、류행병학조사용억욱자평량표、파금삼병사사량표、일상생활능역량표、전면쇠퇴량표등진행측험，취합매련반응-한제성편단장도다태성분석（PCR-RFLP）CST3기인다태성。결과 A등위기인빈솔재MCI조여NC조분별위80.4%화90.9%，B등위기인빈솔재MCI조여NC조분별위19.6%화9.1%，량조비교c2＝7.005，P＝0.008，차이균유통계학의의。재0.05검험수준하，휴대B등위기인（OR：2.279，95% CI：1.064～4.882，P＝0.034）여T2DM발생MCI위험성적관련차이유통계학의의。결론휴대B등위기인시노년T2DM환자발생MCI적위험인소。검측CST3다태성유리우노년T2DM환자인지장애적조기진단。
Objective To investigate the correlation of polymorphism in cystatin C gene (CST3) with mild cognitive impairment (MCI) in the elderly with type 2 diabetes mellitus (T2DM) and to analyze the risk factors for MCI. Methods A total of 156 retired veteran cadres with identified T2DM living in Shanghai were recruited and divided into 2 groups: MCI group and normal cognition (NC) group based on Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-Ⅳ). All subjects were evaluated with cognition scores of Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Self-Rating Anxiety Scale (SAS), Center for Epidemiogical Studies Depression Scale (CES-D), Screening Scale for Parkinson’s disease (SSPD), Activity of Daily Living (ADL), and Global Deterioration Scale (GDS). Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used to detect the polymorphism of CST3. Results The allele A frequency was 80.4% and 90.9% respectively in T2DM-MCI group and T2DM-NC group, and that of allele B were 19.6% and 9.1% respectively. There were significant differences between the 2 groups (Chi-square=7.005, P=0.008). CST3 B allele carrying was a risk factor for MCI in the T2DM elderly (OR=2.279, 95%CI=1.064 to 4.882, P=0.034). Conclusion CST3 B allele carrying is one of the risk factors for MCI in the T2DM elderly. Detection of CST3 polymorphism is helpful in the early diagnosis of MCI for the elderly people with T2DM.
