CAJ | 학술논문

目的：探讨尘螨所致持续性变应性鼻炎（PAR）成年患者生活质量（QOL ）状况，及其经标准化尘螨变应原特异性免疫治疗（SIT ）或药物治疗前、后QOL的改变。方法对2011年4～8月该院确诊的PAR患者行变应原皮肤点刺试验（SPT ），挑选对尘螨过敏的成年患者80例，随机分为SIT组和药物治疗组，每组各40例，在治疗6个月前、后给予鼻结膜炎生活质量调查问卷（RQLQ）量表进行问卷调查；选取40例在该院健康体检的无变应性疾病者作为对照组并予 RQLQ量表进行问卷调查。比较PAR患者与对照组的QOL和PAR患者治疗前、后QOL的变化及两种治疗方法对QOL影响的差异。结果 PAR患者的QOL在RQLQ量表的各个维度及总分方面均高于对照组（P＜0．05），其中在鼻部症状方面受到的影响最为明显。PAR患者RQLQ各维度的积分治疗后均较治疗前下降（P＜0．05），且SIT 组RQLQ各维积分均低于药物治疗组（P＜0．05）。结论成年PAR患者，经SIT或药物治疗后，其QOL较治疗前改善，且经SIT治疗的患者QOL改善更明显。
목적：탐토진만소치지속성변응성비염（PAR）성년환자생활질량（QOL ）상황，급기경표준화진만변응원특이성면역치료（SIT ）혹약물치료전、후QOL적개변。방법대2011년4～8월해원학진적PAR환자행변응원피부점자시험（SPT ），도선대진만과민적성년환자80례，수궤분위SIT조화약물치료조，매조각40례，재치료6개월전、후급여비결막염생활질량조사문권（RQLQ）량표진행문권조사；선취40례재해원건강체검적무변응성질병자작위대조조병여 RQLQ량표진행문권조사。비교PAR환자여대조조적QOL화PAR환자치료전、후QOL적변화급량충치료방법대QOL영향적차이。결과 PAR환자적QOL재RQLQ량표적각개유도급총분방면균고우대조조（P＜0．05），기중재비부증상방면수도적영향최위명현。PAR환자RQLQ각유도적적분치료후균교치료전하강（P＜0．05），차SIT 조RQLQ각유적분균저우약물치료조（P＜0．05）。결론성년PAR환자，경SIT혹약물치료후，기QOL교치료전개선，차경SIT치료적환자QOL개선경명현。
Objective To explore the health-relate quality of life(QOL) status of adult persistent allergic rhinitis (PAR);the change of QOL of pro-post specific immunotherapy (SIT) and pharmacotherapy .Methods Skin prick tests(SPT) were performed on PAR patients .According to the results ,80 adult cases that were allergic to dermatophagoides were enrolled in ENT outpatient clinic of affiliated hospital of Nantong University from April to August 2011 .The patients were randomly allocated to receive either specific immunotherapy(n=40) or pharmacotherapy (n=40) ,all of them were given RQLQ before and after half-year treatment ;40 cases without any allergic diseases were chosen from ENT in-patient department ,and were given RQLQ .The scores of previous treatment of the PAR group were compared with health control group ,then compared with the scores of post-treatment ,and also compared the scores of post-treatment between the immunotherapy group and pharmacotherapy group .Results The scores of the PAR patients were higher than that of health control patients in all dimensions of RQLQ (P< 0 .05) ,and the most troublesome problems were nasal symptoms .The scores of the patients who received SIT were evidently lower than that of pro-treatment in all dimensions of RQLQ(P<0 .05) ,the scores of the patients who received medical treatment were also lower than before (P<0 .05) , and the scores of the SIT group were lower than the pharmacotherapy group (P<0 .05) .Conclusion The QOL of adult patients with PAR was improved after SIT or drug treatment ,and QOL improvement is more obvious treat by SIT .