CAJ | 학술논문

目的：探讨降钙素原（PCT）在卒中相关性肺炎（SAP）的诊断、治疗及预后判断过程中的作用。方法检测27例SAP患者、31例卒中对照者的血清中PCT、高敏C反应蛋白（hs-CRP）浓度，计算临床肺部感染评分（CPIS），并进行统计学分析。结果SAP组患者的CPSI、hs-CRP、血清PCT浓度明显高于卒中组（P＜0．01），在治疗好转后均明显下降。在SAP患者中，死亡组患者的PCT浓度明显高于存活组（P＜0．01）。相关分析显示，血清PCT浓度与CPSI呈正相关。ROC曲线分析结果显示，血清PCT诊断SAP的临界值为0．9ng/mL，其灵敏度及特异度分别为88．6％和79．3％，明显优于hs-CRP的诊断价值。结论SAP患者的血清PCT明显升高，且与患者的预后相关，对SAP诊断的价值明显高于hs-CRP。PCT可以作为SAP患者诊断、病情和预后评估的较好临床指标之一。
목적：탐토강개소원（PCT）재졸중상관성폐염（SAP）적진단、치료급예후판단과정중적작용。방법검측27례SAP환자、31례졸중대조자적혈청중PCT、고민C반응단백（hs-CRP）농도，계산림상폐부감염평분（CPIS），병진행통계학분석。결과SAP조환자적CPSI、hs-CRP、혈청PCT농도명현고우졸중조（P＜0．01），재치료호전후균명현하강。재SAP환자중，사망조환자적PCT농도명현고우존활조（P＜0．01）。상관분석현시，혈청PCT농도여CPSI정정상관。ROC곡선분석결과현시，혈청PCT진단SAP적림계치위0．9ng/mL，기령민도급특이도분별위88．6％화79．3％，명현우우hs-CRP적진단개치。결론SAP환자적혈청PCT명현승고，차여환자적예후상관，대SAP진단적개치명현고우hs-CRP。PCT가이작위SAP환자진단、병정화예후평고적교호림상지표지일。
Objective To observe the value of procalcitonin (PCT ) in the diagnosis ,treatment and prognosis judgement of stoke-associated pneumonia(SAP) .Methods The serum procalcitonin ,hs-CRP and clinical pulmonary infection scores (CPSI) of two groups were detected :SAP group(including 27 patients of stoke-associated pneumonia) and control group(including 31 healthy ob-jects) .Results The CPSI ,hs-CRP and serum concentration of PCT in SAP group were significantly higher than control group (P<0 .01) ,and decreased significantly when get better after treatment .The serum concentration of PCT in SAP group was significantly higher than control group(P<0 .01) .In SAP group ,the serum concentration of PTC was positively associated with CPSI scorers . Moreover ,the results of ROC analysis showed that the cut-off of serum procalcitonin for the diagnosis of SAP was 0 .9 ng/mL .The sensitivety was 88 .6% and the specifity was 79 .3% ,which was superior to hs-CRP .Conclusion The serum concentration of PCT in SAP patients is higher and it is associated with the prognosis .It might be a better clinical marker for the diagnosis and prognosis of SAP .