当代医学
噹代醫學
당대의학
CHINA CONTEMPORARY MEDICINE
2013年
32期
65-66
,共2页
宫颈癌前病变%人乳头状瘤%相关性
宮頸癌前病變%人乳頭狀瘤%相關性
궁경암전병변%인유두상류%상관성
Cervical precancerous lesion%Human papilloma%Correlation
目的:探讨宫颈癌前病变与人乳头状瘤(HPV)感染的相关性。方法对160例研究对象的宫颈采集的标本进行HPV-DNA定量检测和阴道镜检查,对相关数据进行统计分析。结果160例宫颈病变患者中,宫颈炎、CIN I、CIN Ⅱ及CIN Ⅲ分别为29、36、56和39例,CINI、CINⅡ及CINⅢ患者HPV-DNA阳性率组内比较差异无统计学意义(P﹥0.05),与宫颈炎患者比较差异有统计学意义(χ2=10.5940、30.0550、23.3042,P﹤0.05),CIN患者HPV病毒载量高于宫颈炎患者(t=12.1733、29.1556、19.4403,P﹤0.05),HPV病毒载量随病变严重程度增加而增加。HPV病毒载量在0~0.99、1.00~9.99、10.00~99.9和100.00~范围内,不同病理类型患者组间比较差异有统计学意义(P﹤0.05),随着病变程度加重,HPV病毒载量增加。结论宫颈癌前病变与HPV感染存在着密切的联系,HPV病毒载量与宫颈病变的进展有一定关系。
目的:探討宮頸癌前病變與人乳頭狀瘤(HPV)感染的相關性。方法對160例研究對象的宮頸採集的標本進行HPV-DNA定量檢測和陰道鏡檢查,對相關數據進行統計分析。結果160例宮頸病變患者中,宮頸炎、CIN I、CIN Ⅱ及CIN Ⅲ分彆為29、36、56和39例,CINI、CINⅡ及CINⅢ患者HPV-DNA暘性率組內比較差異無統計學意義(P﹥0.05),與宮頸炎患者比較差異有統計學意義(χ2=10.5940、30.0550、23.3042,P﹤0.05),CIN患者HPV病毒載量高于宮頸炎患者(t=12.1733、29.1556、19.4403,P﹤0.05),HPV病毒載量隨病變嚴重程度增加而增加。HPV病毒載量在0~0.99、1.00~9.99、10.00~99.9和100.00~範圍內,不同病理類型患者組間比較差異有統計學意義(P﹤0.05),隨著病變程度加重,HPV病毒載量增加。結論宮頸癌前病變與HPV感染存在著密切的聯繫,HPV病毒載量與宮頸病變的進展有一定關繫。
목적:탐토궁경암전병변여인유두상류(HPV)감염적상관성。방법대160례연구대상적궁경채집적표본진행HPV-DNA정량검측화음도경검사,대상관수거진행통계분석。결과160례궁경병변환자중,궁경염、CIN I、CIN Ⅱ급CIN Ⅲ분별위29、36、56화39례,CINI、CINⅡ급CINⅢ환자HPV-DNA양성솔조내비교차이무통계학의의(P﹥0.05),여궁경염환자비교차이유통계학의의(χ2=10.5940、30.0550、23.3042,P﹤0.05),CIN환자HPV병독재량고우궁경염환자(t=12.1733、29.1556、19.4403,P﹤0.05),HPV병독재량수병변엄중정도증가이증가。HPV병독재량재0~0.99、1.00~9.99、10.00~99.9화100.00~범위내,불동병리류형환자조간비교차이유통계학의의(P﹤0.05),수착병변정도가중,HPV병독재량증가。결론궁경암전병변여HPV감염존재착밀절적련계,HPV병독재량여궁경병변적진전유일정관계。
Objective To investigate the correlation between cervical precancerous lesion and human papillomavirus (HPV)infection. Methods The cervical specimen of 160 patients were determined by HPV-DNA and colposcopy, the related data was for statistical analysis. Results Among 160 patients with cervical lesions ,there was 29 cases with cervicitis, 36 cases with CINI, 56 cases with CINⅡ,and the positive rate of HPV DNA of 39 patients with CINⅢwas no statistical significant difference in the same group (P>0.05), there was statistical significant compared with patients with cervicitis (χ2=10.5940、30.0550、23.3042,P﹤0.05), the HPV viral load of CIN patients exceeded the cervicitis patients (t=12.1733、29.1556、19.4403,P﹤0.05), HPV viral load increased with the disease severity. HPV viral load was in the scope of 0-0.99, 1.00-9.99、10.00-99.9 and 100.00-, the patients with different pathological types compared between groups ,there was statistical significant (P﹤0.05), the more exacerbation of pathological changed, HPV viral load increased. Conclusion There is close relation between cervical precancerous lesion and human papillomavirus (HPV)infection, and there is the relationship between HPV viral load and the progress of cervical lesions.