CAJ | 학술논문

目的探讨抑癌基因程序性细胞死亡因子4（PDCD4）在脑星形细胞肿瘤中的表达与肿瘤侵袭性的相关性。方法用免疫组化检测PDCD4在脑星形细胞肿瘤中的表达情况，同时通过测量核磁共振影像上的瘤周水肿低信号范围，并与免疫组化表达结果作比较分析。结果在星形细胞肿瘤中随着肿瘤的恶性程度的增加，PDCD4表达下调；肿瘤恶性程度与肿瘤侵袭性指标MRI扫描图像上表现的瘤周水肿低信号范围分级呈正相关（P＜0．05），而PDCD4表达与肿瘤侵袭性指标MRI扫描图像上瘤周水肿低信号范围分级呈负相关（P＜0．01）。结论PDCD4可以作为脑星形细胞肿瘤的预后判断指标和侵袭指标之一。
목적탐토억암기인정서성세포사망인자4（PDCD4）재뇌성형세포종류중적표체여종류침습성적상관성。방법용면역조화검측PDCD4재뇌성형세포종류중적표체정황，동시통과측량핵자공진영상상적류주수종저신호범위，병여면역조화표체결과작비교분석。결과재성형세포종류중수착종류적악성정도적증가，PDCD4표체하조；종류악성정도여종류침습성지표MRI소묘도상상표현적류주수종저신호범위분급정정상관（P＜0．05），이PDCD4표체여종류침습성지표MRI소묘도상상류주수종저신호범위분급정부상관（P＜0．01）。결론PDCD4가이작위뇌성형세포종류적예후판단지표화침습지표지일。
Objective To investigate the relationship of programmed cell death 4(PDCD4) with the invasion of astrocytic glio-mas .Methods Using the immunohistochemical method to detect the expression of PDCD4 in astrocytic gliomas in different grades . Measuring the peritumoral low-density area on MRI scan ,then compared with the results of immunohistochemical expression .Re-sults The downregulation of PDCD4 was with the increasing of the malignant grade of astrocytic gliomas .The tumor grade malig-nancy was positively correlated with the grade of the peritumoral low-density area on MRI scan(P<0 .05) ,while the expression of PDCD4 was negatively correlated with the grade of astrocytic gliomas (P<0 .01) .Conclusion PDCD4 might serve as one of the in-dicators of invasion and malignant phenotype for astrocytic gliomas .