CAJ | 학술논문

目的：探讨Caveolin-1和增殖细胞核抗原（PCNA）在食管鳞癌中的蛋白表达及其意义。方法应用免疫组织化学SP法分别检测150例食管鳞癌组织和35例正常食管黏膜组织（距离癌灶边缘5 cm以上经病理证实）中Caveolin-1和PCNA蛋白表达情况。结果 Caveolin-1蛋白在食管鳞癌组织中的表达明显高于正常食管黏膜组织（P＜0．05），且其表达与淋巴结转移密切相关；PCNA蛋白在正常食管黏膜组织中的表达明显低于食管鳞癌组织（P＜0．05），且其蛋白表达与患者年龄、淋巴结转移和肿瘤长度密切相关；Caveolin-1和PCNA蛋白的表达呈正相关（r＝0．266，P＜0．05）。结论 Caveolin-1与 PCNA蛋白过表达可能与食管鳞癌的发生、发展以及浸润转移有关。
목적：탐토Caveolin-1화증식세포핵항원（PCNA）재식관린암중적단백표체급기의의。방법응용면역조직화학SP법분별검측150례식관린암조직화35례정상식관점막조직（거리암조변연5 cm이상경병리증실）중Caveolin-1화PCNA단백표체정황。결과 Caveolin-1단백재식관린암조직중적표체명현고우정상식관점막조직（P＜0．05），차기표체여림파결전이밀절상관；PCNA단백재정상식관점막조직중적표체명현저우식관린암조직（P＜0．05），차기단백표체여환자년령、림파결전이화종류장도밀절상관；Caveolin-1화PCNA단백적표체정정상관（r＝0．266，P＜0．05）。결론 Caveolin-1여 PCNA단백과표체가능여식관린암적발생、발전이급침윤전이유관。
Objective To explore the expression levels and significance of Caveolin-1 and proliferating cell nuclear antigen (PC-NA) in esophageal squamous cell carcinoma .Methods Immunohistochemical SP method was used to detect the expression levels of caveolin-1 and PCNA in 150 cases of esophageal squamous cell carcinoma and 35 cases of normal esophageal squamous cell . Results The expressions of Caveolin-1 in esophageal carcinoma was significantly higher than in normal esophageal mucosa (P<0 .05) ,caveolin-1 was related to lymph node metastasis ;The expressions of PCNA in esophageal carcinoma was significantly higher than in normal esophageal mucosa(P<0 .05) ,PCNA was related to age ,lymph node metastasis and tumor size .The expression of Caveolin-1 was positively correlated with PCNA (r=0 .266 ,P<0 .05) .Conclusion Caveolin-1 and PCNA overexpression might be related to the occurrence ,development and metastasis of esophageal squamous cell carcinomas .