CAJ | 학술논문

目的：分析高脂血症性急性胰腺炎（HLAP）的临床特点和预后情况。方法回顾性分析2007年6月至2012年6月住院诊断为 HLAP的患者72例及83例急性胆源性胰腺炎（ABP）患者作为对照。比较两组患者的临床资料，分析血清三酰甘油（TG）水平与HLAP疾病严重程度的相关性。结果 HLAP组的年龄、血淀粉酶均低于ABP组（P＜0．05）。 HLAP组伴发脂肪肝和2型糖尿病的发生率均明显高于ABP组（P＜0．05），伴发高血压差异无统计学意义（P＞0．05）。两组Ranson、APACHE-Ⅱ、胰腺Balthazar CT 评分差异均无统计学意义（P＞0．05）。HLAP组的AP复发率明显高于ABP组（P＜0．05）；而手术率和病死率差异无统计学意义（P＞0．05）。HLAP的TG水平与Ronson、APACHE-Ⅱ、胰腺Balthazar CT 评分均无相关性（P＞0．05）。结论 HLAP多见于中青年人，血淀粉酶升高不显著，易伴发脂肪肝和2型糖尿病及其他并发症，并且容易反复发作，其病情严重程度与血清TG水平无相关性。
목적：분석고지혈증성급성이선염（HLAP）적림상특점화예후정황。방법회고성분석2007년6월지2012년6월주원진단위 HLAP적환자72례급83례급성담원성이선염（ABP）환자작위대조。비교량조환자적림상자료，분석혈청삼선감유（TG）수평여HLAP질병엄중정도적상관성。결과 HLAP조적년령、혈정분매균저우ABP조（P＜0．05）。 HLAP조반발지방간화2형당뇨병적발생솔균명현고우ABP조（P＜0．05），반발고혈압차이무통계학의의（P＞0．05）。량조Ranson、APACHE-Ⅱ、이선Balthazar CT 평분차이균무통계학의의（P＞0．05）。HLAP조적AP복발솔명현고우ABP조（P＜0．05）；이수술솔화병사솔차이무통계학의의（P＞0．05）。HLAP적TG수평여Ronson、APACHE-Ⅱ、이선Balthazar CT 평분균무상관성（P＞0．05）。결론 HLAP다견우중청년인，혈정분매승고불현저，역반발지방간화2형당뇨병급기타병발증，병차용역반복발작，기병정엄중정도여혈청TG수평무상관성。
Objective To analyze the clinical features and prognosis of hyperlipidemic acute sancreatitis (HLAP) .Methods A retrospective study was conducted in a cohort of 72 hyperlipidemic acute pancreatitis patients admitted in hospital from June 2007 to June 2012 .83 patients with acute biliary pancreatitis (ABP) diagnosed were served as control group .The clinical data of both groups were compared between the two groups .The correlation between serum triglyceride(TG) levels and disease severity of HLAP was assessed .Results The age and serum amylase levels of the HLAP group were remarkably lower than those of the ABP group (both P<0 .05) .Patients with HLAP had a significantly increased prevalence of fatty liver and type 2 diabetes compared with those with ABP(P<0 .05) ,but no difference of incident hypertension was found (P>0 .05) .The Ranson score ,APACHE-Ⅱ score ,and Bal-thazar CT score were comparable between the two groups (all P>0 .05) .The recurrence risk of HLAP group was strikingly higher than that of ABP group(P<0 .05) ,whereas the surgical operation and mortality rates were not significantly different between the two groups(P>0 .05) .The serum TG levels of HLAP showed no significant correlation with Ronson score ,APACHE-Ⅱ score and Balthazar CT score values(all P>0 .05) .Conclusion HLAP mainly occurs in young to middle-aged people .The serum amylase val-ues of HLAP increased mildly .Patients with HLAP are often accompanied by fatty liver and type 2 diabetes ,and subjected to grea-ter complications and recurrence risk .The severity of HLAP doesn′t correlate with the serum TG levels .