CAJ | 학술논문

目的：观察芬太尼透皮贴剂对难治性带状疱疹后遗神经痛的疗效及不良反应。方法将带状疱疹后遗神经痛患者30例（常规药物联合神经阻滞治疗1个疗程后VAS＞5分）分为曲马多组（T组）、芬太尼组（F组），每组15例。结果两组治疗后VAS评分均降低（P＜0．05），F组更为显著（P＜0．05）。治疗后两组生活质量评分均明显升高（P＜0．05），F组较高（P＜0．05）。F组恶心、呕吐发生率较T组低（ P＞0．05）；F组未出现排尿困难，T组发生率为26．67％（ P＜0．05）；T组在治疗后便秘发生率为40％，F组无便秘情况（P＜0．05）；F组嗜睡的发生率比T组高（P＜0．05）；两组均未发生呼吸抑制。结论芬太尼透皮贴剂用于难治性带状疱疹后遗神经痛镇痛效果好，不良反应较少。
목적：관찰분태니투피첩제대난치성대상포진후유신경통적료효급불량반응。방법장대상포진후유신경통환자30례（상규약물연합신경조체치료1개료정후VAS＞5분）분위곡마다조（T조）、분태니조（F조），매조15례。결과량조치료후VAS평분균강저（P＜0．05），F조경위현저（P＜0．05）。치료후량조생활질량평분균명현승고（P＜0．05），F조교고（P＜0．05）。F조악심、구토발생솔교T조저（ P＞0．05）；F조미출현배뇨곤난，T조발생솔위26．67％（ P＜0．05）；T조재치료후편비발생솔위40％，F조무편비정황（P＜0．05）；F조기수적발생솔비T조고（P＜0．05）；량조균미발생호흡억제。결론분태니투피첩제용우난치성대상포진후유신경통진통효과호，불량반응교소。
Objective To evaluate the effects of fentanyl transdermal system on intractable postherpetic neuralgia .Methods 30 patients(after 1 course of conventional drugs with nerve block therapy ,VAS score>5 points)were randomly divided into tramadol group(group T ) and fentanyl group(group F) ,15 cases in each group .Results VAS of the two groups decreased after treatment (P<0 .05) ,group F decreased more significantly(P<0 .05) .The quality of life scores after treatment in two groups were signifi-cantly increased(P<0 .05) ,group F scoring was higher(P<0 .05) .The incidence of side reaction ,nausea and vomiting was lower in group F(P>0 .05) .The incidence of dysuria was 26 .67% in group T ,and there was no dysuria in group F(P<0 .05) .Constipation of group T was 40% after treatment(P<0 .05) .The incidence of somnolence of group F was higher than T group(P<0 .05) .The two groups were no respiratory depression .Conclusion Fentanyl transdermal system for intractable postherpetic neuralgia has good analgesic effect ,less side effect ,and well-tolerated .