检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2014年
8期
1023-1024,1027
,共3页
中药%慢性淋巴细胞性甲状腺炎%甲状腺功能减退%左旋甲状腺素钠
中藥%慢性淋巴細胞性甲狀腺炎%甲狀腺功能減退%左鏇甲狀腺素鈉
중약%만성림파세포성갑상선염%갑상선공능감퇴%좌선갑상선소납
traditional Chinese medicine%chronic lymphocytic thyroiditis%hypothyroidism%levothyroxine
目的:观察二仙汤加芪海消瘿汤治疗慢性淋巴细胞性甲状腺炎(慢甲炎)伴甲状腺功能减退症的临床疗效。方法选择慢甲炎伴甲状腺功能减退症70例,皆用左旋甲状腺素片维持甲状腺激素正常,分为两组,治疗组在左旋甲状腺素基础上加二仙汤和芪海消瘿汤方,对照组单用左旋甲状腺素。治疗前后观察两组临床疗效,并检测两组血清总甲状腺素(T4)、血清总三碘甲腺原氨酸(T3)、促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、甲状腺球蛋白抗体(TGAb)、甲状腺过氧化物酶抗体(TPOAb)、血常规、肝肾功。结果治疗前两组T3、T4、TSH、FT3、FT4、TGAb、TPOAb、血常规比较差异无统计学意义(P>0.05),肝肾功能皆正常,具可比性。经治疗后治疗组有效率为91.4%,对照组为74.3%,两组比较差异有统计学意义( P<0.05)。治疗后两组T3、T4、FT3、FT4、TSH皆正常,治疗组TGAb、TPOAb降低,与治疗前相比差异有统计学意义(P<0.05),与对照组相比差异有统计学意义(P<0.05)。治疗组左旋甲状腺素用量明显减少,与治疗前相比差异有统计学意义(P<0.05)。治疗组肿大的甲状腺较治疗前缩小,相比差异有统计学意义(P<0.05);对照组治疗前、后甲状腺大小变化不大,与治疗组相比差异有统计学意义(P<0.05)。结论二仙汤加芪海消瘿汤能调节慢甲炎伴甲状腺功能减退患者免疫功能,降低抗体水平,减少左旋甲状腺素用量,缩小肿大的甲状腺。
目的:觀察二仙湯加芪海消癭湯治療慢性淋巴細胞性甲狀腺炎(慢甲炎)伴甲狀腺功能減退癥的臨床療效。方法選擇慢甲炎伴甲狀腺功能減退癥70例,皆用左鏇甲狀腺素片維持甲狀腺激素正常,分為兩組,治療組在左鏇甲狀腺素基礎上加二仙湯和芪海消癭湯方,對照組單用左鏇甲狀腺素。治療前後觀察兩組臨床療效,併檢測兩組血清總甲狀腺素(T4)、血清總三碘甲腺原氨痠(T3)、促甲狀腺激素(TSH)、遊離三碘甲腺原氨痠(FT3)、血清遊離甲狀腺素(FT4)、甲狀腺毬蛋白抗體(TGAb)、甲狀腺過氧化物酶抗體(TPOAb)、血常規、肝腎功。結果治療前兩組T3、T4、TSH、FT3、FT4、TGAb、TPOAb、血常規比較差異無統計學意義(P>0.05),肝腎功能皆正常,具可比性。經治療後治療組有效率為91.4%,對照組為74.3%,兩組比較差異有統計學意義( P<0.05)。治療後兩組T3、T4、FT3、FT4、TSH皆正常,治療組TGAb、TPOAb降低,與治療前相比差異有統計學意義(P<0.05),與對照組相比差異有統計學意義(P<0.05)。治療組左鏇甲狀腺素用量明顯減少,與治療前相比差異有統計學意義(P<0.05)。治療組腫大的甲狀腺較治療前縮小,相比差異有統計學意義(P<0.05);對照組治療前、後甲狀腺大小變化不大,與治療組相比差異有統計學意義(P<0.05)。結論二仙湯加芪海消癭湯能調節慢甲炎伴甲狀腺功能減退患者免疫功能,降低抗體水平,減少左鏇甲狀腺素用量,縮小腫大的甲狀腺。
목적:관찰이선탕가기해소영탕치료만성림파세포성갑상선염(만갑염)반갑상선공능감퇴증적림상료효。방법선택만갑염반갑상선공능감퇴증70례,개용좌선갑상선소편유지갑상선격소정상,분위량조,치료조재좌선갑상선소기출상가이선탕화기해소영탕방,대조조단용좌선갑상선소。치료전후관찰량조림상료효,병검측량조혈청총갑상선소(T4)、혈청총삼전갑선원안산(T3)、촉갑상선격소(TSH)、유리삼전갑선원안산(FT3)、혈청유리갑상선소(FT4)、갑상선구단백항체(TGAb)、갑상선과양화물매항체(TPOAb)、혈상규、간신공。결과치료전량조T3、T4、TSH、FT3、FT4、TGAb、TPOAb、혈상규비교차이무통계학의의(P>0.05),간신공능개정상,구가비성。경치료후치료조유효솔위91.4%,대조조위74.3%,량조비교차이유통계학의의( P<0.05)。치료후량조T3、T4、FT3、FT4、TSH개정상,치료조TGAb、TPOAb강저,여치료전상비차이유통계학의의(P<0.05),여대조조상비차이유통계학의의(P<0.05)。치료조좌선갑상선소용량명현감소,여치료전상비차이유통계학의의(P<0.05)。치료조종대적갑상선교치료전축소,상비차이유통계학의의(P<0.05);대조조치료전、후갑상선대소변화불대,여치료조상비차이유통계학의의(P<0.05)。결론이선탕가기해소영탕능조절만갑염반갑상선공능감퇴환자면역공능,강저항체수평,감소좌선갑상선소용량,축소종대적갑상선。
Objective To explore the curative effects of ER Xian Tang and QI Hai Xiao Ying Tang for the treatment of chronic lymphocytic thyroiditis (CLT ) complicated with hypothyroidism .Methods A total of 70 pa-tients with CLT complicate with hypothyroidism were divided into treatment group ,given Er Xian Tang ,Qi Hai Xiao Ying Tang and levothyroxine sodium tablets ,and control group ,given evothyroxine sodium tablets .Curative effects , and serum levels of triiodothyronine (T3) ,thyroxine (T4) ,free triiodothyronine (FT3) ,free thyroxine (FT4) ,thyro-tropic-stimulating hormone (TSH) ,thyroglobulin antibody (TGAb) ,thyroid peroxidase antibody (TPOAb) and so on were compared between the two groups .Results Before treatment ,the differences of levels of T3 ,T4 ,TSH ,FT3 , FT4 ,TGAb ,TPOAb and indexes of routine blood test between the two groups were not significant (P>0 .05) ,and liver function of patients in the two groups were all without abnormality .After treatment ,the effective rate in treat-ment group was 91 .4% ,being significantly different with the 74 .3% in control group (P<0 .05) .After treatment , levels of T3 ,T4 ,FT3 ,FT4 and TSH in the two groups all return to normal range ,and levels of TGAb and TPOAb in treatment group were reduced ,being significantly different with levels detected before treatment and with levels of control group (P<0 .05) .In treatment group ,the dosage of levothyroxine reduced significantly (P<0 .05) .Thyroid volume reduced significantly only in treatment group (P<0 .05) .Conclusion Er Xian Tang and Qi Hai Xiao Ying Tang could effectively regulate immune function ,reduce levels of TGAb ,TPOAb and thyroid volume in patients with CLT complicated with hypothyroidism .