医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2013年
20期
57-58
,共2页
阿孜古丽?麦麦提%艾克拜尔?阿布都热衣木%刘加军
阿孜古麗?麥麥提%艾剋拜爾?阿佈都熱衣木%劉加軍
아자고려?맥맥제%애극배이?아포도열의목%류가군
免疫%心力衰竭%细胞因子
免疫%心力衰竭%細胞因子
면역%심력쇠갈%세포인자
Immune%Congestive heart failure%Cytokine
充血性心力衰竭(C H F)是一种复杂的临床症状群,为各种心脏病的严重阶段,其发病率高,它的发生发展过程,除了心肌细胞肥大、凋亡、细胞外基质变化导致心肌重塑外,某些相关细胞因子亦参与了心衰的进程,并起到推波助澜的作用。越来越多的证据表明细胞因子(主要有:肿瘤坏死因子-a、白介素-6)是充血性心力衰竭的病理生理和发病机制中的重要因子,它通过介导左室重构、使 B-2肾上腺素受体失耦联、降低心肌收缩力等作用引发或加重心衰。本文主要探讨心力衰竭时免疫系统中细胞因子的变化。
充血性心力衰竭(C H F)是一種複雜的臨床癥狀群,為各種心髒病的嚴重階段,其髮病率高,它的髮生髮展過程,除瞭心肌細胞肥大、凋亡、細胞外基質變化導緻心肌重塑外,某些相關細胞因子亦參與瞭心衰的進程,併起到推波助瀾的作用。越來越多的證據錶明細胞因子(主要有:腫瘤壞死因子-a、白介素-6)是充血性心力衰竭的病理生理和髮病機製中的重要因子,它通過介導左室重構、使 B-2腎上腺素受體失耦聯、降低心肌收縮力等作用引髮或加重心衰。本文主要探討心力衰竭時免疫繫統中細胞因子的變化。
충혈성심력쇠갈(C H F)시일충복잡적림상증상군,위각충심장병적엄중계단,기발병솔고,타적발생발전과정,제료심기세포비대、조망、세포외기질변화도치심기중소외,모사상관세포인자역삼여료심쇠적진정,병기도추파조란적작용。월래월다적증거표명세포인자(주요유:종류배사인자-a、백개소-6)시충혈성심력쇠갈적병리생리화발병궤제중적중요인자,타통과개도좌실중구、사 B-2신상선소수체실우련、강저심기수축력등작용인발혹가중심쇠。본문주요탐토심력쇠갈시면역계통중세포인자적변화。
CHF Is a complex of clinical symptoms with high incidence,which is serious stage of al kinds of heart disease. It happened in the development process, in addition to myocardial cel hypertrophy, apoptosis, extracel ular matrix cardiac remodeling the change, some related cel factors also participated in the heart failure process, and play a important role. More and more evidence that cel factor is important factor for physiological and pathological on mechanism of congestive heart failure. It is through left ventricular remodeling, make B-2 adrenaline receptor coupling, reduce the lost force of cardiac muscle systole effect such as cause or worsen heart failure. This paper mainly discusses the change of immune system cel s in heart failure.