CAJ | 학술논문

目的：探讨经肝动脉化疗栓塞( TACE)结合二期手术切除治疗原发性进展期肝癌的价值。方法应用肝动脉化疗栓塞结合二期手术切除治疗53例进展期肝癌。结果肿瘤直径为5～17cm，其中最大者为20cm。14例肿瘤待手术时直径缩小30%～40％。53例均获二期手术切除。术后1、3、5年的无瘤生存率分别为69.8%、45.3%、15.1%,中位无瘤生存期为32个月，1、3、5年总体累积生存率为90.5%、60.3%、33.9%，中位累积生存期43个月。结论 TACE结合二期手术切除对进展期原发性肝癌的治疗和提高远期生存率具有一定的价值，是一种有效地治疗措施。
목적：탐토경간동맥화료전새( TACE)결합이기수술절제치료원발성진전기간암적개치。방법응용간동맥화료전새결합이기수술절제치료53례진전기간암。결과종류직경위5～17cm，기중최대자위20cm。14례종류대수술시직경축소30%～40％。53례균획이기수술절제。술후1、3、5년적무류생존솔분별위69.8%、45.3%、15.1%,중위무류생존기위32개월，1、3、5년총체루적생존솔위90.5%、60.3%、33.9%，중위루적생존기43개월。결론 TACE결합이기수술절제대진전기원발성간암적치료화제고원기생존솔구유일정적개치，시일충유효지치료조시。
Objective To evaluate the value of transcatheter hepatic arterial chemoembolization (TACE) combined with secondary hepatectomy for the treatment of the patients with advanced primary liver cancer(PLC). Methods 53 patients with advanced unresectable PLC underwent liver resection at second stage after TACE. Postoperative complications, cancer recurrence rate, and long-term survival rate were followed-up and analyzed.Results The diameter of the tumor is from 5 to 17 centimeters with the most centimeters of 20.The size of tumors decreased from 30%to 40%in 14 patients. All 53 patients underwent hepatectomy at second stage after TACE.The survival rates of tumor-free and 1-, 3 and 5-year after operation were 69.8%,45.3%and 15.1% respectively. The median survival time of tumor-free was 32 months in all patients. Total cumulative survival rates were 90. 5%,60.3%and 33.9%respectively and median cumulative survival time after operation was 43 months .Conclusion Hepatectomy at second stage after TACE was an effective method for the treatment of the patients with advanced PLC and increased long-term survival rate of the patients.